Direct Synthesis of 4-Aryl-1,2,3-triazoles via l2-Promoted Cyclization under Metal- and Azide-Free Conditions

被引：17

作者：

Huang, Chun ^{[1
]}

Geng, Xiao ^{[2
,3
]}

Zhao, Peng ^{[1
]}

Zhou, You ^{[1
]}

Yu, Xiao-Xiao ^{[1
]}

Wang, Li-Sheng ^{[1
]}

Wu, Yan-Dong ^{[1
]}

Wu, An-Xin ^{[1
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China

[2] Taizhou Univ, Adv Res Inst, Taizhou 318000, Zhejiang, Peoples R China

[3] Taizhou Univ, Dept Chem, Taizhou 318000, Zhejiang, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 19期

基金：

中国国家自然科学基金;

关键词：

CATALYZED SYNTHESIS; SODIUM-AZIDE; CYCLOADDITION; 1H-1,2,3-TRIAZOLES; 1,2,3-TRIAZOLES; UREAS;

D O I：

10.1021/acs.joc.1c01702

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We herein report an iodine-mediated formal [2 + 2 + 1] cyclization of methyl ketones, p-toluenesulfonyl hydrazines, and 1-aminopyridinium iodide for preparation of 4-aryl-NH-1,2,3-triazoles under metal- and azide-free conditions. Notably, this is achieved using p-toluenesulfonyl hydrazines and 1-aminopyridinium iodide as azide surrogates, providing a novel route toNH-1,2,3-triazoles. Furthermore, this approach provides rapid and practical access to potent inhibitors of indoleamine 2,3-dioxygenase (IDO).

引用

页码：13664 / 13672

页数：9

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