Revisited gene regulation in bacteriophage λ

被引：92

作者：

Dodd, IB ^{[1
]}

Shearwin, KE ^{[1
]}

Egan, JB ^{[1
]}

机构：

[1] Univ Adelaide, Sch Mol & Biomed Sci, Discipline Biochem, Adelaide, SA 5005, Australia

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2005年 / 15卷 / 02期

关键词：

D O I：

10.1016/j.gde.2005.02.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The contribution of bacteriophage X to gene control research is far from over. A revised model of the X genetic switch includes extra cooperativity through octamerization of the cl repressor protein, mediated by long-range DNA looping. Structural analysis reveals remarkably subtle transcriptional activation by cl. The action of cl, activation by cll, and aspects of antitermination by N and Q all confirm the utility and versatility of simple, weak adhesive interactions mediated by nucleic acid tethers. New genetic and quantitative analysis of the X gene network is challenging cherished ideas about how complex behaviours emerge from this regulatory system.

引用

页码：145 / 152

页数：8

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