Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

被引：439

作者：

Shen, HM

Peters, A

Baron, B

Zhu, XD

Storb, U ^{[1
]}

机构：

[1] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60617 USA

[2] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60617 USA

[3] Univ Chicago, Dept Pathol, Chicago, IL 60617 USA

[4] Univ Chicago, Dept Med, Chicago, IL 60617 USA

来源：

SCIENCE | 1998年 / 280卷 / 5370期

关键词：

D O I：

10.1126/science.280.5370.1750

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immunoglobulin (Ig) genes are hypermutated in B lymphocytes that are the precursors to memory B cells. The mutations are linked to transcription initiation, but non-Ig promoters are permissible for the mutation process; thus, other genes expressed in mutating B cells may also be subject to somatic hypermutation. Significant mutations were not observed in c-MYC, S14, or alpha-fetoprotein (AFP) genes, but BCL-6 was highly mutated in a large proportion of memory B cells of normal individuals. The mutation pattern was similar to that of Ig genes.

引用

页码：1750 / 1752

页数：3

共 22 条

[1] Small deletions occur in highly conserved regions of the LAZ3/BCL6 major translocation cluster in one case of non-Hodgkin's lymphoma without 3q27 translocation
Bernardin, F
CollyndHooghe, M
Quief, S
Bastard, C
Leprince, D
Kerckaert, JP
[J]. ONCOGENE, 1997, 14 (07) : 849 - 855
[2] ELEMENTS REGULATING SOMATIC HYPERMUTATION OF AN IMMUNOGLOBULIN-KAPPA GENE - CRITICAL ROLE FOR THE INTRON ENHANCER MATRIX ATTACHMENT REGION
BETZ, AG
MILSTEIN, C
GONZALEZFERNANDEZ, A
PANNELL, R
LARSON, T
NEUBERGER, MS
[J]. CELL, 1994, 77 (02) : 239 - 248
[3] PCR fidelity of Pfu DNA polymerase and other thermostable DNA polymerases
Cline, J
Braman, JC
Hogrefe, HH
[J]. NUCLEIC ACIDS RESEARCH, 1996, 24 (18) : 3546 - 3551
[4] IDENTIFICATION AND NUCLEOTIDE-SEQUENCE OF A HUMAN LOCUS HOMOLOGOUS TO THE V-MYC ONCOGENE OF AVIAN MYELOCYTOMATOSIS VIRUS MC29
COLBY, WW
CHEN, EY
SMITH, DH
LEVINSON, AD
[J]. NATURE, 1983, 301 (5902) : 722 - 725
[5] NUCLEOTIDE-SEQUENCE OF THE HUMAN C-MYC LOCUS - PROVOCATIVE OPEN READING FRAME WITHIN THE 1ST EXON
GAZIN, C
DEDINECHIN, SD
HAMPE, A
MASSON, JM
MARTIN, P
STEHELIN, D
GALIBERT, F
[J]. EMBO JOURNAL, 1984, 3 (02) : 383 - 387
[6] STRUCTURE, POLYMORPHISM, AND NOVEL REPEATED DNA ELEMENTS REVEALED BY A COMPLETE SEQUENCE OF THE HUMAN ALPHA-FETOPROTEIN GENE
GIBBS, PEM
ZIELINSKI, R
BOYD, C
DUGAICZYK, A
[J]. BIOCHEMISTRY, 1987, 26 (05) : 1332 - 1343
[7] EQUIPOTENT MOUSE RIBOSOMAL-PROTEIN PROMOTERS HAVE A SIMILAR ARCHITECTURE THAT INCLUDES INTERNAL SEQUENCE ELEMENTS
HARIHARAN, N
KELLEY, DE
PERRY, RP
[J]. GENES & DEVELOPMENT, 1989, 3 (11) : 1789 - 1800
[8] VARIABLE REGION GENE ANALYSIS OF B-CELL SUBSETS DERIVED FROM A 4-YEAR-OLD CHILD - SOMATICALLY MUTATED MEMORY B-CELLS ACCUMULATE IN THE PERIPHERAL-BLOOD ALREADY AT YOUNG AGE
KLEIN, U
KUPPERS, R
RAJEWSKY, K
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (04) : 1383 - 1393
[9] Klotz EL, 1996, J IMMUNOL, V157, P4458
[10] Migliazza A., 1997, Blood, V90, p177A

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