Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

被引：440
作者：
Shen, HM
Peters, A
Baron, B
Zhu, XD
Storb, U [1 ]
机构：
[1] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60617 USA
[2] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60617 USA
[3] Univ Chicago, Dept Pathol, Chicago, IL 60617 USA
[4] Univ Chicago, Dept Med, Chicago, IL 60617 USA
来源：
SCIENCE | 1998年 / 280卷 / 5370期
关键词：
D O I：
10.1126/science.280.5370.1750
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Immunoglobulin (Ig) genes are hypermutated in B lymphocytes that are the precursors to memory B cells. The mutations are linked to transcription initiation, but non-Ig promoters are permissible for the mutation process; thus, other genes expressed in mutating B cells may also be subject to somatic hypermutation. Significant mutations were not observed in c-MYC, S14, or alpha-fetoprotein (AFP) genes, but BCL-6 was highly mutated in a large proportion of memory B cells of normal individuals. The mutation pattern was similar to that of Ig genes.
引用
收藏
页码：1750 / 1752
页数：3
相关论文
共 22 条
[1]   Small deletions occur in highly conserved regions of the LAZ3/BCL6 major translocation cluster in one case of non-Hodgkin's lymphoma without 3q27 translocation [J].
Bernardin, F ;
CollyndHooghe, M ;
Quief, S ;
Bastard, C ;
Leprince, D ;
Kerckaert, JP .
ONCOGENE, 1997, 14 (07) :849-855
[2]   ELEMENTS REGULATING SOMATIC HYPERMUTATION OF AN IMMUNOGLOBULIN-KAPPA GENE - CRITICAL ROLE FOR THE INTRON ENHANCER MATRIX ATTACHMENT REGION [J].
BETZ, AG ;
MILSTEIN, C ;
GONZALEZFERNANDEZ, A ;
PANNELL, R ;
LARSON, T ;
NEUBERGER, MS .
CELL, 1994, 77 (02) :239-248
[3]   PCR fidelity of Pfu DNA polymerase and other thermostable DNA polymerases [J].
Cline, J ;
Braman, JC ;
Hogrefe, HH .
NUCLEIC ACIDS RESEARCH, 1996, 24 (18) :3546-3551
[4]   IDENTIFICATION AND NUCLEOTIDE-SEQUENCE OF A HUMAN LOCUS HOMOLOGOUS TO THE V-MYC ONCOGENE OF AVIAN MYELOCYTOMATOSIS VIRUS MC29 [J].
COLBY, WW ;
CHEN, EY ;
SMITH, DH ;
LEVINSON, AD .
NATURE, 1983, 301 (5902) :722-725
[5]   NUCLEOTIDE-SEQUENCE OF THE HUMAN C-MYC LOCUS - PROVOCATIVE OPEN READING FRAME WITHIN THE 1ST EXON [J].
GAZIN, C ;
DEDINECHIN, SD ;
HAMPE, A ;
MASSON, JM ;
MARTIN, P ;
STEHELIN, D ;
GALIBERT, F .
EMBO JOURNAL, 1984, 3 (02) :383-387
[6]   STRUCTURE, POLYMORPHISM, AND NOVEL REPEATED DNA ELEMENTS REVEALED BY A COMPLETE SEQUENCE OF THE HUMAN ALPHA-FETOPROTEIN GENE [J].
GIBBS, PEM ;
ZIELINSKI, R ;
BOYD, C ;
DUGAICZYK, A .
BIOCHEMISTRY, 1987, 26 (05) :1332-1343
[7]   EQUIPOTENT MOUSE RIBOSOMAL-PROTEIN PROMOTERS HAVE A SIMILAR ARCHITECTURE THAT INCLUDES INTERNAL SEQUENCE ELEMENTS [J].
HARIHARAN, N ;
KELLEY, DE ;
PERRY, RP .
GENES & DEVELOPMENT, 1989, 3 (11) :1789-1800
[8]   VARIABLE REGION GENE ANALYSIS OF B-CELL SUBSETS DERIVED FROM A 4-YEAR-OLD CHILD - SOMATICALLY MUTATED MEMORY B-CELLS ACCUMULATE IN THE PERIPHERAL-BLOOD ALREADY AT YOUNG AGE [J].
KLEIN, U ;
KUPPERS, R ;
RAJEWSKY, K .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (04) :1383-1393
[9]  
Klotz EL, 1996, J IMMUNOL, V157, P4458
[10]  
Migliazza A., 1997, Blood, V90, p177A
123