Maternal Influences over Offspring Allergic Responses

被引：26
作者：
Cook-Mills, Joan M. [1 ]
机构：
[1] Northwestern Univ, Div Allergy Immunol, Feinberg Sch Med, Chicago, IL 60611 USA
来源：
CURRENT ALLERGY AND ASTHMA REPORTS | 2015年 / 15卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Allergy; Neonate; Fetus; Dendritic cells; Corticosterone; alpha-Tocopherol; TOCOPHEROL TRANSFER PROTEIN; OVA-SENSITIZED RATS; VITAMIN-E; ALPHA-TOCOPHEROL; ASTHMA RISK; T-CELLS; GAMMA-TOCOPHEROL; BREAST-MILK; DENDRITIC CELLS; MURINE MODEL;
D O I：
10.1007/s11882-014-0501-1
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Asthma occurs as a result of complex interactions of environmental and genetic factors. Clinical studies and animal models of asthma indicate offspring of allergic mothers have increased risk of development of allergies. Environmental factors including stress-induced corticosterone and vitamin E isoforms during pregnancy regulate the risk for offspring development of allergy. In this review, we discuss mechanisms for the development of allergic disease early in life, environmental factors that may impact the development of risk for allergic disease early in life, and how the variation in global prevalence of asthma may be explained, at least in part, by some environmental components.
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页数：10
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