Population genetics of familial Mediterranean fever: a review

被引：44
|
作者：
Yepiskoposyan, Levon [1 ]
Harutyunyan, Ashot [1 ]
机构：
[1] Inst Man, Yerevan 375019, Armenia
来源：
EUROPEAN JOURNAL OF HUMAN GENETICS | 2007年 / 15卷 / 09期
关键词：
familial Mediterranean fever; MEFV; classically affected populations;
D O I：
10.1038/sj.ejhg.5201869
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review, some principal population genetic features of familial Mediterranean fever (FMF) are considered. These relate to the time and the place of founder mutations' origins, the role of ancient migrations and contacts between populations in the spatial spreading of the disorder, the influence of environmental factors and cultural traditions on the rate of FMF incidence, and possible selective advantage in carriers of FMF causing gene (MEFV) mutations.
引用
收藏
页码：911 / 916
页数：6
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