Aberrant Mesenteric Migration of Spirocerca lupi Larvae Causing Necrotizing Eosinophilic Arteritis, Thrombosis, and Intestinal Infarction in Dogs

被引：7

作者：

Brenner, Ori Jacob ^{[1
]}

Botero-Anug, Ana Maria ^{[2
]}

Rojas, Alicia ^{[3
]}

Hahn, Shelley ^{[4
]}

Baneth, Gad ^{[3
]}

机构：

[1] Weizmann Inst Sci, Dept Vet Resources, 234 Herzl St, IL-76100 Rehovot, Israel

[2] Pathovet Diagnost Vet Pathol Serv, Rehovot, Israel

[3] Hebrew Univ Jerusalem, Koret Sch Vet Med, Rehovot, Israel

[4] Tufts Univ, Cummings Sch Vet Med, North Grafton, MA USA

来源：

VETERINARY PATHOLOGY | 2020年 / 57卷 / 02期

关键词：

avermectins; canine; histopathology; nematode; PCR; prophylaxis; spirocerosis;

D O I：

10.1177/0300985819887531

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

This report presents a novel canine condition in 32 dogs in which aberrant migration of Spirocerca lupi larvae through mesenteric arteries, instead of gastric arteries, led to small or large intestinal infarction. This form of spirocercosis was first recognized in Israel in 2013 and is currently ongoing. Typical clinical signs were anorexia and weakness of 3 to 4 days and, less frequently, vomiting and diarrhea, followed by collapse, bloody diarrhea, and severe vomiting. Exploratory laparotomy showed 1 or more infarcted and often perforated intestinal segments in all cases. Microscopically, there was intestinal mucosal to transmural coagulative necrosis and mesenteric multifocal necrotizing eosinophilic arteritis, thrombosis, hemorrhage, and early fibroplasia. Third-stage S. lupi larvae were identified by morphologic features in 9 of 32 (28%) cases, and the species was confirmed by polymerase chain reaction in 4 cases. Nearly 50% of the dogs had been receiving prophylactic therapy, which did not prevent this form of spirocercosis.

引用

页码：281 / 285

页数：5