Adenovirus-mediated gene transfer of Bcl-xL impedes neurite regeneration in vitro

被引：14

作者：

Oshitari, T

Okada, S

Tokuhisa, T

Adachi-Usami, E

机构：

[1] Chiba Univ, Grad Sch Med, Dept Ophthalmol & Visual Sci, Chuo Ku, Chiba 2608670, Japan

[2] Chiba Univ, Grad Sch Med, Dept Dev Genet, Chuo Ku, Chiba 2608670, Japan

来源：

NEUROREPORT | 2003年 / 14卷 / 08期

关键词：

adenovirus vector; apoptosis; Bcl-xL; green fluorescent protein; mouse; regeneration; retinal ganglion cells; tissue culture;

D O I：

10.1097/00001756-200306110-00011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mouse retinal explants were transfected with recombinant adenovirus vector carrying the green fluorescent protein (GFP) gene and the rat bcl-X-L gene (Adeno-Bcl-xL) to determine its ability to protect retinal ganglion cells against apoptotic cell death and to promote retinal ganglion cell neurite regeneration. Adeno-Bcl-xL-incubated retinas had reduced apoptosis compared with controls.

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收藏

页码：1159 / 1162

页数：4

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