Toxicological, antibacterial and anti-quorum activity of extracts of medicinal plants Betula spp., Hypericum spp. and Angelica spp.

Quorum sensing plays an important role in the infectious process development in plants, animals and humans. Inhibiting this phenomenon may be a new way to treat bacterial infections in therapeutic practice. Similar studies are being conducted all over the world and several approaches to inhibiting quorum-dependent processes are currently being presented. Folk remedies, which include, in particular, medicinal plants, can become an alternative tool for fighting bacterial pathogens to traditionally used antibacterial substances that have lost their former effectiveness, due to the widespread spread of antibiotic resistance. In this work, the toxicological, antibacterial and anti-quorum properties of the extracts of Betula spp. leaf, Hypericum spp. herb and Angelica spp. root were studied. Testing the extracts of Betula spp. leaf, Hypericum spp. herb and Angelica spp. root showed a minor toxicological effect on the recombinant luminescent strain Escherichia coli, which is manifested at high concentrations of the substance being tested. Similar results were obtained on another test object Stylonychia mytilus, for which the maximum toxicological effect was observed in the concentration range of 5.0-10.0 mg / ml for Betula spp. leaf and Hypericum spp. herb, and 10.0 mg / ml for Angelica spp. root. Against this background, quorum-inhibiting activity of the studied plant extracts was registered, increasing in the series Angelica spp. -> Hypericum spp. -> Betula spp.