Analysis of the Promoter Region of Human Dopamine Receptor D1

被引：2
|
作者：
Wu, Xue [1 ]
Xu, Feng-ling [1 ]
Wang, Bao-jie [1 ]
Yao, Jun [1 ]
机构：
[1] China Med Univ, Sch Forens Med, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China
来源：
JOURNAL OF MOLECULAR NEUROSCIENCE | 2018年 / 65卷 / 04期
基金：
中国国家自然科学基金;
关键词：
DRD1; Transcriptional regulator; Promoter; Neuropsychiatric disorder; GENE; SCHIZOPHRENIA; DRD1; POLYMORPHISMS; TRANSCRIPTION; ASSOCIATION; DEPENDENCE; DISORDER; DISEASE;
D O I：
10.1007/s12031-018-1116-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Dysregulation of dopamine receptor D1 (DRD1) is involved in multiple neuropsychiatric disorders. The 5' regulatory region of DRD1 has not been characterized fully. We applied the luciferase assay and the electrophoretic mobility shift assay to explore the activity of the 5' regulatory region of DRD1 in SH-SY5Y and 293T cells. We found that the promoter region of DRD1 corresponded to positions - 1250 to + 250 in the DNA sequence, and the putative core promoter region was from - 113 to + 250 (transcriptional start site of exon, +1). The sequence 5'-gggacgcgcgggcggggtgggctgtgccccgcgggaaccccgccggcctgtgcgcttgctg-3' was identified as a possible transcription factor-binding domain. Further research is warranted to explore the function of the 5' regulatory region of DRD1.
引用
收藏
页码：438 / 443
页数：6
相关论文
共 50 条
  • [41] Prefrontal D1 dopamine signaling is required for temporal control
    Narayanan, Nandakumar S.
    Land, Benjamin B.
    Solder, John E.
    Deisseroth, Karl
    DiLeone, Ralph J.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (50) : 20726 - 20731
  • [42] Association of dopamine receptor D1 (DRD1) polymorphisms with risperidone treatment response in Chinese schizophrenia patients
    Huo, Ran
    Wei, Zhiyun
    Xiong, Yuyu
    Jiang, Jie
    Liu, Yichen
    Yan, Yucai
    Shi, Jiajun
    Li, Wenqiang
    Cui, Donghong
    Xing, Qinghe
    He, Lin
    Qin, Shengying
    NEUROSCIENCE LETTERS, 2015, 584 : 178 - 183
  • [43] Acute dopamine D1 and D2 receptor stimulation does not modulate mismatch negativity (MMN) in healthy human subjects
    Sumie Leung
    Rodney J. Croft
    Torsten Baldeweg
    Pradeep J. Nathan
    Psychopharmacology, 2007, 194 : 443 - 451
  • [44] Inhibition of Geranylgeranylacetone on cholecystokinin-B receptor, BDNF and dopamine D1 receptor induced by morphine
    Guo, Ningning
    Zhang, Le
    Fan, Wei
    Bai, Liping
    Zhang, Xianwen
    Shi, Zhizhou
    Bai, Jie
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 588 : 23 - 28
  • [45] Dopamine D1 receptor availability is not associated with delusional ideation measures of psychosis proneness
    Matheson, Granville J.
    Plaven-Sigray, Pontus
    Louzolo, Anais
    Borg, Jacqueline
    Farde, Lars
    Petrovic, Predrag
    Cervenka, Simon
    SCHIZOPHRENIA RESEARCH, 2020, 222 : 175 - 184
  • [46] Frontal Lobe Synaptic Plasticity in Development and Disease: Modulation by the Dopamine D1 Receptor
    Selemon, Lynn D.
    CURRENT PHARMACEUTICAL DESIGN, 2014, 20 (32) : 5194 - 5201
  • [47] Renal function and genetic variation in dopamine D1 receptor: is the case strong enough ?
    Kiryluk, Krzysztof
    KIDNEY INTERNATIONAL, 2009, 76 (10) : 1019 - 1022
  • [48] Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation
    Mosher, Laura J.
    Cadeddu, Roberto
    Yen, Sabrina
    Staudinger, Jeffrey L.
    Traccis, Francesco
    Fowler, Stephen C.
    Maguire, Jamie L.
    Bortolato, Marco
    PSYCHONEUROENDOCRINOLOGY, 2019, 108 : 53 - 61
  • [49] Stomach gastrin is regulated by sodium via PPAR-α and dopamine D1 receptor
    Xu, Peng
    Gildea, John J.
    Zhang, Chi
    Konkalmatt, Prasad
    Santiago, Santiago
    Wang, Dora Bigler
    Tran, Hanh T.
    Jose, Pedro A.
    Felder, Robin A.
    JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2020, 64 (02) : 53 - 65
  • [50] Dopamine D1 Receptor Agonist PET Tracer Development: Assessment in Nonhuman Primates
    Barret, Olivier
    Zhang, Lei
    Alagille, David
    Constantinescu, Cristian C.
    Sandiego, Christine
    Papin, Caroline
    Sullivan, Jenna M.
    Morley, Thomas
    Carroll, Vincent M.
    Seibyl, John
    Chen, Jianqing
    Lee, Chewah
    Villalobos, Anabella
    Gray, David
    McCarthy, Timothy J.
    Tamagnan, Gilles
    JOURNAL OF NUCLEAR MEDICINE, 2021, 62 (09) : 1307 - 1313
12345