Meroterpenoid enantiomers from Ganoderma sinensis

被引：20
作者：
Cao, Wen-Wen [1 ,2 ]
Luo, Qi [2 ,3 ]
Cheng, Yong-Xian [2 ]
Wang, Shu-Mei [1 ]
机构：
[1] Guangdong Pharmaceut Univ, Guangzhou 510006, Guangdong, Peoples R China
[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
[3] Univ Chinese Acad Sci, Yuquan Rd 19, Beijing 100049, Peoples R China
来源：
FITOTERAPIA | 2016年 / 110卷
基金：
中国国家自然科学基金;
关键词：
Ganoderma sinensis; Zizhines A-F; Meroterpenoids; Extracellular matrix production; MUSHROOM; LUCIDUM; METABOLITES; INHIBITORS; COCHLEAR; POTENT;
D O I：
10.1016/j.fitote.2016.03.003
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Zizhines A-F (1-6), six pairs of new meroterpenoid enantiomers and a known meroterpenoid (7) were isolated from the fruiting bodies of Ganoderma sinensis. The structures and absolute configurations of the new substances were assigned by spectroscopic and computational methods. All the compounds apart from 7 were evaluated for their inhibition on extracellular matrix component (fibronectin) generation by using TGF-beta 1-induced rat kidney tubular epithelial cells. Although none of them was found to be active in these cells, the present findings add new facets for the chemistry of Ganoderma. (C) 2016 Published by Elsevier B.V.
引用
收藏
页码：110 / 115
页数：6
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