High-dose chemotherapy and autologous stem cell transplantation in treating paediatric malignancies

被引：1

作者：

Valteau-Couanet, D. ^{[1
]}

Dufour, C. ^{[1
]}

Hartmann, O. ^{[1
]}

机构：

[1] Inst Gustave Roussy, Dept Pediat, F-94805 Villejuif, France

来源：

ONCOLOGIE | 2007年 / 9卷 / 12期

关键词：

high-dose chemotherapy; autologous stem cell transplantation; solid tumour; paediatrics;

D O I：

10.1007/s10269-007-0791-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Most paediatric malignancies can be cured with conventional chemotherapy. Autologous stem cell transplantation makes it possible to dramatically increase chemotherapy doses and cure tumours that were resistant to conventional chemotherapy, such as high-risk neuroblastoma and metastatic Ewing sarcoma. High-dose chemotherapy and autologous transplantation are major tools in treating patients who have very high-risk malignancies. In patients with brain tumours, it aims at improving prognosis and decreasing sequelae. Maintenance therapy has been developed to follow high-dose chemotherapy and treat minimal, persistent, residual disease.

引用

页码：827 / 831

页数：5

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