Transcriptional interference mediated by retrotransposons within the genome of their host:: lessons from alleles of the white gene from Drosophila melanogaster

被引：4

作者：

Desset, S ^{[1
]}

Vaury, C ^{[1
]}

机构：

[1] INSERM, Fac Med, U384, FR-63001 Clermont Ferrand, France

来源：

CYTOGENETIC AND GENOME RESEARCH | 2005年 / 110卷 / 1-4期

关键词：

D O I：

10.1159/000084954

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Systematic sequencing of model genomes has accelerated our knowledge on genome structure and shown that a large proportion of intergenic regions are made up of mobile element families. Among them, retrotransposons that are mobilized via an RNA intermediate and thus do not excise during their replication cycle are certainly essential factors able to imprint novel and heritable transcriptional regulation within the genome of their host. Today, a crucial complement to the systematic sequencing data is thus to elucidate the potential role of these elements in the regulation of nearby genes, and ultimately in the evolution of eukaryotic genomes. Copyright (c) 2005 S. Karger AG, Basel.

引用

页码：209 / 214

页数：6

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