Noncoding RNAs: biology and applications-a Keystone Symposia report

被引：15

作者：

Cable, Jennifer

Heard, Edith ^{[1
,2
]}

Hirose, Tetsuro ^{[3
,4
]}

Prasanth, Kannanganattu, V ^{[5
]}

Chen, Ling-Ling ^{[6
,7
,8
]}

Henninger, Jonathan E. ^{[9
]}

Quinodoz, Sofia A. ^{[10
]}

Spector, David L. ^{[11
]}

Diermeier, Sarah D. ^{[12
]}

Porman, Allison M. ^{[13
]}

Kumar, Dhiraj ^{[14
]}

Feinberg, Mark W. ^{[15
]}

Shen, Xiaohua ^{[16
,17
]}

Unfried, Juan Pablo ^{[18
]}

Johnson, Rory ^{[19
,20
,21
,22
]}

Chen, Chun-Kan ^{[23
,24
]}

Wilusz, Jeremy E. ^{[25
]}

Lempradl, Adelheid ^{[26
]}

McGeary, Sean E. ^{[9
,27
,28
]}

Wahba, Lamia ^{[24
,29
]}

Pyle, Anna Marie ^{[30
,31
]}

Hargrove, Amanda E. ^{[32
]}

Simon, Matthew D. ^{[33
]}

Marcia, Marco ^{[34
]}

Przanowska, Roza K. ^{[35
]}

Chang, Howard Y. ^{[23
,36
]}

Jaffrey, Samie R. ^{[37
]}

Contreras, Lydia M. ^{[38
]}

Chen, Qi ^{[39
]}

Shi, Junchao ^{[39
]}

Mendell, Joshua T. ^{[40
,41
]}

He, Lin ^{[42
]}

Song, Erwei ^{[43
,44
,45
,46
,47
]}

Rinn, John L. ^{[48
,49
]}

Lalwani, Mukesh Kumar ^{[50
]}

Kalem, Murat Can ^{[51
]}

Chuong, Edward B. ^{[52
,53
]}

Maquat, Lynne E. ^{[54
,55
]}

Liu, Xuhang ^{[56
]}

机构：

[1] European Mol Biol Lab EMBL, Heidelberg, Germany

[2] Coll France, Paris, France

[3] Osaka Univ, Grad Sch Frontier Biosci, Suita, Osaka, Japan

[4] Hokkaido Univ, Inst Genet Med, Sapporo, Hokkaido, Japan

[5] Univ Illinois, Canc Ctr Illinois, Dept Cell & Dev Biol, Urbana, IL USA

[6] Univ Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Mol Biol,Shanghai Key Lab Mol Andro, Shanghai, Peoples R China

[7] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China

[8] Univ Chinese Acad Sci, Sch Life Sci, Hangzhou Inst Adv Study, Hangzhou, Peoples R China

[9] Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA

[10] Princeton Univ, Dept Chem & Biol Engn, Princeton, NJ 08544 USA

[11] SUNY Stony Brook, Cold Spring Harbor Lab, Cold Spring Harbor & Genet Program, Stony Brook, NY 11794 USA

[12] Univ Otago, Dept Biochem, Dunedin, New Zealand

[13] Univ Colorado, Biochem & Mol Genet Dept, Anschutz Med Campus, Aurora, CO USA

[14] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA

[15] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Cardiovasc Div, Boston, MA 02115 USA

[16] Tsinghua Univ, Tsinghua Peking Joint Ctr Life Sci, Sch Med, Beijing, Peoples R China

[17] Tsinghua Univ, Sch Life Sci, Beijing, Peoples R China

[18] Univ Navarra UNAV, Ctr Appl Med Res CIMA, Dept Gene Therapy & Regulat Gene Express, Pamplona, Spain

[19] Bern Univ Hosp, Dept Med Oncol, Inselspital, Bern, Switzerland

[20] Univ Bern, Dept BioMed Res, Bern, Switzerland

[21] Univ Coll Dublin, Sch Biol & Environm Sci, Dublin, Ireland

[22] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dublin, Ireland

[23] Stanford Univ, Ctr Personal Dynam Regulomes, Stanford, CA 94305 USA

[24] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

[25] Univ Penn, Dept Biochem & Biophys, Perelman Sch Med, Philadelphia, PA 19104 USA

[26] Van Andel Res Inst, Dept Metab & Nutr Programming, Grand Rapids, MI USA

[27] MIT, Howard Hughes Med Inst, Cambridge, MA USA

[28] MIT, Dept Biol, Cambridge, MA USA

[29] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA

[30] Yale Sch Med, Dept Genet, New Haven, CT USA

[31] Connecticut & Howard Hughes Med Inst, Chevy Chase, MD USA

[32] Duke Univ, Dept Chem, Durham, NC 27706 USA

[33] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA

[34] European Mol Biol Lab EMBL Grenoble, Grenoble, France

[35] Univ Virginia, Sch Med, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

[36] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

[37] Cornell Univ, Dept Pharmacol, Weill Med Coll, New York, NY 10021 USA

[38] Univ Texas Austin, McKetta Dept Chem Engn, Austin, TX 78712 USA

[39] Univ Calif Riverside, Div Biomed Sci, Sch Med, Riverside, CA 92521 USA

[40] Univ Texas Southwestern Med Ctr Dallas, Dept Mol Biol, Harold C Simmons Comprehens Canc Ctr, Hamon Ctr Regenerat Sci & Med, Dallas, TX 75390 USA

[41] Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX USA

[42] Univ Calif Berkeley, Div Cellular & Dev Biol, Mol & Cell Biol Dept, Berkeley, CA 94720 USA

[43] Sun Yat Sen Univ, Med Res Ctr, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Sun Yat Sen Mem Hosp, Guangzhou, Peoples R China

[44] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Breast Tumor Ctr, Guangzhou, Peoples R China

[45] Sun Yat Sen Univ, Zhongshan Sch Med, Bioland Lab, Guangzhou, Peoples R China

[46] Sun Yat Sen Univ, Zhongshan Sch Med, Program Mol Med, Guangzhou, Peoples R China

[47] Chinese Acad Sci Guangzhou, Guangzhou Inst Biomed & Hlth, Fountain Valley Inst Life Sci, Guangzhou, Peoples R China

[48] Univ Colorado, BioFrontiers Inst, Dept Biochem, Boulder, CO 80309 USA

[49] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA

[50] Univ Edinburgh, BHF Ctr Cardiovasc Sci, Queens Med Res Inst, Edinburgh, Midlothian, Scotland

来源：

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | 2021年 / 1506卷 / 01期

基金：

美国国家科学基金会;

关键词：

circRNA; noncoding RNA; lncRNA; nuclear condensate; phase transition; piRNA; transcription; Xist; CIRCULAR RNAS; TERMINAL REPEAT; X-CHROMOSOME; XIST RNA; INTEGRATOR COMPLEX; CRYSTAL-STRUCTURE; PHASE-SEPARATION; CHROMATIN STATE; GENE-EXPRESSION; LNCRNA;

D O I：

10.1111/nyas.14713

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding RNAs play important roles in regulating transcription, epigenetic modifications, translation, and cell signaling. Roles for noncoding RNAs in disease mechanisms are also being uncovered, and several species have been identified as potential drug targets. On May 11-14, 2021, the Keystone eSymposium "Noncoding RNAs: Biology and Applications" brought together researchers working in RNA biology, structure, and technologies to accelerate both the understanding of RNA basic biology and the translation of those findings into clinical applications.

引用

页码：118 / 141

页数：24

共 174 条

[1] circRNA Biogenesis Competes with Pre-mRNA Splicing
Ashwal-Fluss, Reut
Meyer, Markus
Pamudurti, Nagarjuna Reddy
Ivanov, Andranik
Bartok, Osnat
Hanan, Mor
Evantal, Naveh
Memczak, Sebastian
Rajewsky, Nikolaus
Kadener, Sebastian
[J]. MOLECULAR CELL, 2014, 56 (01) : 55 - 66
[2] Immobilization of Proteins in the Nucleolus by Ribosomal Intergenic Spacer Noncoding RNA
Audas, Timothy E.
Jacob, Mathieu D.
Lee, Stephen
[J]. MOLECULAR CELL, 2012, 45 (02) : 147 - 157
[3] Endogenous retroviral promoter exaptation in human cancer
Babaian, Artem
Mager, Dixie L.
[J]. MOBILE DNA, 2016, 7 : 1 - 21
[4] Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II
Baillat, D
Hakimi, MA
Näär, AM
Shilatifard, A
Cooch, N
Shiekhattar, R
[J]. CELL, 2005, 123 (02) : 265 - 276
[5] Balas Maggie M, 2018, Noncoding RNA Res, V3, P108, DOI 10.1016/j.ncrna.2018.03.001
[6] Bartel, 2021, PAIRING MICRORNA 3 R, DOI [10.1101/2021.04.13.439700, DOI 10.1101/2021.04.13.439700]
[7] Nuclear stress bodies: a heterochromatin affair?
Biamonti, G
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (06) : 493 - 498
[8] Noncoding Transcripts in Sense and Antisense Orientation Regulate the Epigenetic State of Ribosomal RNA Genes
Bierhoff, H.
Schmitz, K.
Maass, F.
Ye, J.
Grummt, I.
[J]. NUCLEAR ORGANIZATION AND FUNCTION, 2010, 75 : 357 - 364
[9] Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix
Brown, Jessica A.
Bulkley, David
Wang, Jimin
Valenstein, Max L.
Yario, Therese A.
Steitz, Thomas A.
Steitz, Joan A.
[J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2014, 21 (07) : 633 - 640
[10] Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals
Carone, Benjamin R.
Fauquier, Lucas
Habib, Naomi
Shea, Jeremy M.
Hart, Caroline E.
Li, Ruowang
Bock, Christoph
Li, Chengjian
Gu, Hongcang
Zamore, Phillip D.
Meissner, Alexander
Weng, Zhiping
Hofmann, Hans A.
Friedman, Nir
Rando, Oliver J.
[J]. CELL, 2010, 143 (07) : 1084 - 1096

← 1 2 3 4 5 6 7 8 9 10 →