TOTAL SYNTHESIS OF NATURAL PRODUCTS AND MEDICINAL MOLECULES VIA CHELATION-CONTROLLED DIASTEREOSELECTIVE HYDRIDE REDUCTION OF AMINO KETONES

The chiral beta-amino alcohols are widely presented in the natural products, privileged ligands, and medicinal molecules. In the past decades, the construction of anti-beta-amino alcohols have attracted in the interest of synthetic chemists. A number of studies indicated that the chelation-controlled hydride reduction approach is straightforward for the preparation of anti-beta-amino alcohol motifs in high yield with excellent diastereoselectivity and they can be used as chiral building block in the total synthesis of natural products and medicinal molecules. The aim of this review is to highlight application of chelation-controlled hydride reduction in total synthesis of natural products and medicinal molecules on the basis of a collection of recent literature studies.