Progression of Renal Damage in Glycogen Storage Disease Type I Is Associated to Hyperlipidemia: A Multicenter Prospective Italian Study

被引：15

作者：

Melis, Daniela ^{[1
]}

Cozzolino, Mariarosaria ^{[2
]}

Minopoli, Giorgia ^{[2
]}

Balivo, Francesca ^{[2
]}

Parini, Rossella ^{[3
]}

Rigoldi, Miriam ^{[3
]}

Paci, Sabrina ^{[4
]}

Dionisi-Vici, Carlo ^{[5
]}

Burlina, Alberto ^{[6
]}

Andria, Generoso ^{[2
]}

Parenti, Giancarlo ^{[2
]}

机构：

[1] Univ Naples Federico II, Azienda Osped, Welf Dept Pediat, I-80100 Naples, Italy

[2] Univ Naples Federico II, Sez Pediat, Dept Med Sci, I-80100 Naples, Italy

[3] Osped San Gerardo, Dept Pediat, Monza, Italy

[4] Osped San Paolo, Dept Pediat, Milan, Italy

[5] Bambino Gesu Pediat Hosp, Div Med Pathol, Rome, Italy

[6] Univ Padua, Div Med Pathol, Padua, Italy

来源：

JOURNAL OF PEDIATRICS | 2015年 / 166卷 / 04期

关键词：

NEPHROPATHY; EXPRESSION;

D O I：

10.1016/j.jpeds.2014.12.015

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Angiotensin converting enzyme (ACE)- inhibitors decrease glomerular hyperfiltration but not microalbuminuria and proteinuria in glycogen storage disease type I. In the current study, we demonstrated that severe hyperlipidemia is associated with ACE-inhibitor ineffectiveness. We underline the importance of adequate metabolic control in glycogen storage disease type I. A combination therapy with ACE-inhibitors and lipid lowering drugs might be considered.

引用

页码：1079 / 1082

页数：4

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