Progression of Renal Damage in Glycogen Storage Disease Type I Is Associated to Hyperlipidemia: A Multicenter Prospective Italian Study

被引:15
|
作者
Melis, Daniela [1 ]
Cozzolino, Mariarosaria [2 ]
Minopoli, Giorgia [2 ]
Balivo, Francesca [2 ]
Parini, Rossella [3 ]
Rigoldi, Miriam [3 ]
Paci, Sabrina [4 ]
Dionisi-Vici, Carlo [5 ]
Burlina, Alberto [6 ]
Andria, Generoso [2 ]
Parenti, Giancarlo [2 ]
机构
[1] Univ Naples Federico II, Azienda Osped, Welf Dept Pediat, I-80100 Naples, Italy
[2] Univ Naples Federico II, Sez Pediat, Dept Med Sci, I-80100 Naples, Italy
[3] Osped San Gerardo, Dept Pediat, Monza, Italy
[4] Osped San Paolo, Dept Pediat, Milan, Italy
[5] Bambino Gesu Pediat Hosp, Div Med Pathol, Rome, Italy
[6] Univ Padua, Div Med Pathol, Padua, Italy
关键词
NEPHROPATHY; EXPRESSION;
D O I
10.1016/j.jpeds.2014.12.015
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Angiotensin converting enzyme (ACE)- inhibitors decrease glomerular hyperfiltration but not microalbuminuria and proteinuria in glycogen storage disease type I. In the current study, we demonstrated that severe hyperlipidemia is associated with ACE-inhibitor ineffectiveness. We underline the importance of adequate metabolic control in glycogen storage disease type I. A combination therapy with ACE-inhibitors and lipid lowering drugs might be considered.
引用
收藏
页码:1079 / 1082
页数:4
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