Correlation between atherogenic index and oxidative stress in coronary artery disease patients presenting to a tertiary hospital

Cardiovascular disease (CAD) is now understood to be a complex illness impacted by a person's genetic make-up, as well as their surroundings and mental well-being. Participants with coronary artery disease (CAD) and age- and gender-matched control subjects were compared for levels of lipid parameters, oxidative stress, antioxidant markers, as well as the link between the atherogenic index and oxidative stress. In this study, 62 individuals with clinically confirmed coronary artery disease were compared to 62 healthy controls of same age and sex. FPG was measured, lipid profiles were examined, and oxidative markers like malondialdehyde (MDA), F2 isoprostanes (F2iso), glutathione S-transferase (GST), superoxide dismutase (SOD), vitamin-C, and vitamin-E were measured in the samples collected from the subjects. These tests were performed on the samples collected. Compared to healthy controls, CAD patients had considerably higher levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and anti-inflammatory index (AI) than did healthy individuals, but HDL-c levels in CAD patients were significantly lower. Patients with coronary artery disease (CAD) had higher levels of MDA and F2 isoprostanes, whereas their enzymatic antioxidants GST and SOD and nonenzymatic antioxidants Vitamin-C and Vitamin-E had decreased levels. An important influence on AI was revealed to be the existence of signs of oxidative stress. F2iso and MDA indicators, as well as antioxidants GST, VIT-C and VIT-E all had a substantial impact on the atherogenic index in this study's findings.