Six new indole alkaloids from Gelsemium sempervirens Ait. f.

被引：41

作者：

Kogure, N ^{[1
]}

Nishiya, C ^{[1
]}

Kitajima, M ^{[1
]}

Takayama, H ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 35期

基金：

日本学术振兴会;

关键词：

indole alkaloid; Gelsemium; structure elucidation; NMR; total synthesis; isomerization; solvent effect;

D O I：

10.1016/j.tetlet.2005.06.136

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

One new yohimbane and five new sarpagine-type indole alkaloids were isolated from the radix of Gelsemium sempervirens Ait. f., and their structures were determined by spectroscopic analysis, chemical conversion or total synthesis. It was found that 2-acyl sarpagine-type alkaloids possessing an N-b-methyl group take a keto-amino structure or a transannular form in solution depending on the solvent. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5857 / 5861

页数：5

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