Six new indole alkaloids from Gelsemium sempervirens Ait. f.

被引：41
作者：
Kogure, N [1 ]
Nishiya, C [1 ]
Kitajima, M [1 ]
Takayama, H [1 ]
机构：
[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 35期
基金：
日本学术振兴会;
关键词：
indole alkaloid; Gelsemium; structure elucidation; NMR; total synthesis; isomerization; solvent effect;
D O I：
10.1016/j.tetlet.2005.06.136
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
One new yohimbane and five new sarpagine-type indole alkaloids were isolated from the radix of Gelsemium sempervirens Ait. f., and their structures were determined by spectroscopic analysis, chemical conversion or total synthesis. It was found that 2-acyl sarpagine-type alkaloids possessing an N-b-methyl group take a keto-amino structure or a transannular form in solution depending on the solvent. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5857 / 5861
页数：5
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