EFFECTS OF DRUG BETAMETHASONE ON HEMATOLOGICAL PARAMETERS OF RATTUS NORVEGICUS (BERKENHOUT 1769) IN VIVO CONDITIONS

被引：1

作者：

Haskovic, Edhem ^{[1
]}

Herenda, Safija ^{[2
]}

Herenda, Amina ^{[1
]}

Haskovic, Denis ^{[3
]}

Haskovic, Ena ^{[4
]}

Selimovic, Amina ^{[5
]}

机构：

[1] Univ Sarajevo, Fac Sci, Dept Biol, Sarajevo, Bosnia & Herceg

[2] Univ Sarajevo, Fac Sci, Dept Chem, Sarajevo, Bosnia & Herceg

[3] Univ Sarajevo, Clin Ctr, Org Unit Clin Pathol Cytol & Human Genet, Sarajevo, Bosnia & Herceg

[4] Univ Sarajevo, Clin Ctr, Org Unit Clin Biochem Immunol, Sarajevo, Bosnia & Herceg

[5] Univ Sarajevo, Clin Ctr, Pediat Clin, Sarajevo, Bosnia & Herceg

来源：

JOURNAL OF IMAB | 2022年 / 28卷 / 03期

关键词：

Glucocorticoid; hematology; in vivo con-dition; L-SELECTIN; GLUCOCORTICOIDS; NEUTROPHILS; EXPRESSION; CORTICOSTEROIDS; LEUKOCYTE; APOPTOSIS; MONOCYTES; KINETICS;

D O I：

10.5272/jimab.2022283.4525

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucocorticoids prevent or suppress the full inflam-matory response to the infectious, immunological or physi-cal agents by inhibiting early inflammatory events such as edema or cell exudation. The main effect of glucocorticoids on the inflammatory process is the inhibition or recruitment of neutrophils and monocytes. In this study, the effect of the glucocorticoid betamethasone on the hematological pa-rameters of rats of the species Rattus norvegicus Berkenhout 1769 was examined in vivo. Betamethasone has been shown to affect the values of hematological param-eters four hours after application and leads to a significant decrease in the prevalence of lymphocytes and monocytes, but also leads to a statistically significant increase in eryth-rocyte count, hemoglobin concentration and hematocrit values.

引用

页码：4525 / 4531

页数：7

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