Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder

被引：0

作者：

Mazumder, Atiqul Haq ^{[1
]}

Barnett, Jennifer ^{[2
]}

Isometsae, Erkki Tapio ^{[3
,4
]}

Lindberg, Nina ^{[3
,4
]}

Torniainen-Holm, Minna ^{[5
]}

Laehteenvuo, Markku ^{[6
,7
]}

Lahdensuo, Kaisla ^{[7
,8
]}

Kerkelae, Martta ^{[1
]}

Ahola-Olli, Ari ^{[7
]}

Hietala, Jarmo ^{[9
,10
]}

Kampman, Olli ^{[11
,12
]}

Kieseppae, Tuula ^{[3
,4
,7
,8
]}

Jukuri, Tuomas ^{[1
,7
]}

Haekkinen, Katja ^{[6
,7
]}

Cederloef, Erik ^{[5
]}

Haaki, Willehard ^{[7
,9
]}

Kajanne, Risto ^{[7
]}

Wegelius, Asko ^{[3
,4
,5
,7
]}

Maennynsalo, Teemu ^{[7
,13
]}

Niemi-Pynttaeri, Jussi ^{[7
,13
]}

Suokas, Kimmo ^{[7
,11
]}

Loennqvist, Jouko ^{[5
,14
]}

Tiihonen, Jari ^{[6
,15
,16
]}

Paunio, Tiina ^{[3
,4
,5
,14
]}

Vainio, Seppo Juhani ^{[17
,18
,19
,20
]}

Palotie, Aarno ^{[7
,8
,21
,22
]}

Niemelae, Solja ^{[9
,10
]}

Suvisaari, Jaana ^{[5
]}

Veijola, Juha ^{[1
,23
]}

机构：

[1] Univ Oulu, Dept Psychiat, Res Unit Clin Neurosci, Oulu 90014, Finland

[2] Univ Cambridge, Cambridge Cognit, Cambridge CB25 9TU, England

[3] Univ Hosp, Dept Psychiat, Helsinki 00029, Finland

[4] Univ Helsinki, Helsinki 00029, Finland

[5] Finnish Inst Hlth & Welf THL, Mental Hlth Unit, Helsinki 00271, Finland

[6] Univ Eastern Finland, Niuvanniemi Hosp, Dept Forens Psychiat, Kuopio 70240, Finland

[7] Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki 00014, Finland

[8] Mehilainen, Pohjoinen Hesperiankatu 17 C, Helsinki 00260, Finland

[9] Univ Turku, Dept Psychiat, Turku 20014, Finland

[10] Turku Univ Hosp, Dept Psychiat, Turku 20521, Finland

[11] Tampere Univ, Fac Med & Hlth Technol, Tampere 33014, Finland

[12] Pirkanmaa Hosp Dist, Dept Psychiat, Tampere 33521, Finland

[13] Social Serv & Hlth Care Sect, Helsinki 00099, Finland

[14] Univ Helsinki, Dept Psychiat, Helsinki 00014, Finland

[15] Karolinska Inst, Dept Clin Neurosci, S-17177 Stockholm, Sweden

[16] Stockholm City Council, Ctr Psychiat Res, S-11364 Stockholm, Sweden

[17] Univ Oulu, Infotech Oulu, Oulu 90014, Finland

[18] Oulu Univ Hosp, Northern Finland Biobank Borealis, Oulu 90220, Finland

[19] Univ Oulu, Fac Biochem & Mol Med, Oulu 90014, Finland

[20] Univ Oulu, Kvantum Inst, Oulu 90014, Finland

[21] Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA

[22] Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA

[23] Oulu Univ Hosp, Dept Psychiat, Oulu 90220, Finland

来源：

BRAIN SCIENCES | 2021年 / 11卷 / 11期

基金：

欧盟地平线“2020”;

关键词：

cognition; visual memory; reaction time; hazardous drinking; PGS; schizophrenia; schizoaffective disorder; bipolar disorder; MODERATE ALCOHOL-USE; COGNITIVE IMPAIRMENT; CONSUMPTION; RISK; OLDER; LIFE; PERFORMANCE; DEPENDENCE; MIDLIFE; COHORT;

D O I：

10.3390/brainsci11111422

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.

引用

页数：18

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