Arabinoxylan ameliorates type 2 diabetes by regulating the gut microbiota and metabolites

被引：73

作者：

Nie, Qixing ^{[1
]}

Hu, Jielun ^{[1
]}

Chen, Haihong ^{[1
]}

Geng, Fang ^{[2
]}

Nie, Shaoping ^{[1
]}

机构：

[1] Nanchang Univ, China Canada Joint Lab Food Sci & Technol Nanchan, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China

[2] Chengdu Univ, Sch Food & Biol Engn, Minist Agr & Rural Affairs, Key Lab Coarse Cereal Proc, Chengdu 610106, Peoples R China

来源：

FOOD CHEMISTRY | 2022年 / 371卷

关键词：

Arabinoxylan; Gut microbiota; Type; 2; diabetes; Bacteria-derived metabolites; DAIDZEIN; IMPACT; EQUOL; ACIDS;

D O I：

10.1016/j.foodchem.2021.131106

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Type 2 diabetes (T2D) is a metabolic disease characterized by hyperglycemia. Intake of dietary fiber is inversely associated with risks of T2D. Here, metabolomics and 16S rRNA gene sequencing were employed to investigate the effects of arabinoxylan on gut microbiota and their metabolites in type 2 diabetic rats. T2D increased the abundance of opportunistic pathogens (such as Desulfovibrio and Klebsiella) and the levels of 12 alpha-hydroxylated bile acids and acylcarnitines (C3) in diabetic rats, which eventually contribute to insulin resistance and hyperglycemia. Supplementation with arabinoxylan promoted the growth of fiber-degrading bacteria to increase shortchain fatty acids (SCFAs), as well as decreased the abundance of opportunistic pathogens. Arabinoxylan treatment also decreased the concentrations of 12 alpha-hydroxylated bile acids, and increased the levels of equol, indolepropionate, and eicosadienoic acid. This study indicated that the beneficial effects of arabinoxylan on T2D may be partially attributed to the modification of gut microbiota and related metabolites.

引用

页数：8

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