How does HTLV-I persist despite a strong cell-mediated immune response?

被引：46
作者：
Asquith, Becca [1 ]
Bangharn, Charles R. M. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Dept Immunol, Wright Fleming Inst, London W2 1PG, England
来源：
TRENDS IN IMMUNOLOGY | 2008年 / 29卷 / 01期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/j.it.2007.09.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that infects human CD4(+) T lymphocytes. Despite its presence in T cells, HTLV-1 causes little overt immunosuppression. This host-virus relationship has therefore been exploited as an excellent model system for studying the dynamic interaction between a persistent retrovirus and the normal human immune system. We use a combination of mathematical and experimental techniques to identify key factors on both sides of the in vivo host-virus interaction that significantly determine HTLV-1 proviral load and disease risk. We develop a model to describe how these factors interact to enable viral persistence.
引用
收藏
页码：4 / 11
页数：8
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