How does HTLV-I persist despite a strong cell-mediated immune response?

被引：46
作者：
Asquith, Becca [1 ]
Bangharn, Charles R. M. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Dept Immunol, Wright Fleming Inst, London W2 1PG, England
来源：
TRENDS IN IMMUNOLOGY | 2008年 / 29卷 / 01期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/j.it.2007.09.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that infects human CD4(+) T lymphocytes. Despite its presence in T cells, HTLV-1 causes little overt immunosuppression. This host-virus relationship has therefore been exploited as an excellent model system for studying the dynamic interaction between a persistent retrovirus and the normal human immune system. We use a combination of mathematical and experimental techniques to identify key factors on both sides of the in vivo host-virus interaction that significantly determine HTLV-1 proviral load and disease risk. We develop a model to describe how these factors interact to enable viral persistence.
引用
收藏
页码：4 / 11
页数：8
相关论文
共 61 条
  • [1] Inefficient cytotoxic T lymphocyte-mediated killing of HIV-1-infected cells in vivo
    Asquith, B
    Edwards, CTT
    Lipsitch, M
    McLean, AR
    [J]. PLOS BIOLOGY, 2006, 4 (04) : 583 - 592
  • [2] An introduction to lymphocyte and viral dynamics: the power and limitations of mathematical analysis
    Asquith, B
    Bangham, CRM
    [J]. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2003, 270 (1525) : 1651 - 1657
  • [3] A functional CD8+ cell assay reveals individual variation in CD8+ cell antiviral efficacy and explains differences in human T-lymphotropic virus type 1 proviral load
    Asquith, B
    Mosley, AJ
    Barfield, A
    Marshall, SEF
    Heaps, A
    Goon, P
    Hanon, E
    Tanaka, Y
    Taylor, GP
    Bangham, CRM
    [J]. JOURNAL OF GENERAL VIROLOGY, 2005, 86 : 1515 - 1523
  • [4] Quantification of the virus-host interaction in human T lymphotropic virus I infection
    Asquith, B
    Mosley, AJ
    Heaps, A
    Tanaka, Y
    Taylor, GP
    McLean, AR
    Bangham, CRM
    [J]. RETROVIROLOGY, 2005, 2 (1)
  • [5] Quantifying HTLV-I dynamics
    Asquith, Becca
    Bangham, Charles R. M.
    [J]. IMMUNOLOGY AND CELL BIOLOGY, 2007, 85 (04) : 280 - 286
  • [6] In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection
    Asquith, Becca
    Zhang, Yan
    Mosley, Angelina J.
    de lara, Catherine M.
    Wallace, Diana L.
    Worth, Andrew
    Kaftantzi, Lambrini
    Meekings, Kiran
    Griffin, George E.
    Tanakall, Yuetsu
    Toughfi, David F.
    Beverley, Peter C.
    Taylorl, Graham P.
    Macallant, Derek C.
    Bangham, Charles R. M.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (19) : 8035 - 8040
  • [7] Cellular immune response to HTLV-1
    Bangham, CRM
    Osame, M
    [J]. ONCOGENE, 2005, 24 (39) : 6035 - 6046
  • [8] Analysis of total human immunodeficiency virus (HIV)-specific CD4+ and CD8+ T-cell responses:: Relationship to viral load in untreated HIV infection
    Betts, MR
    Ambrozak, DR
    Douek, DC
    Bonhoeffer, S
    Brenchley, JM
    Casazza, JP
    Koup, RA
    Picker, LJ
    [J]. JOURNAL OF VIROLOGY, 2001, 75 (24) : 11983 - 11991
  • [9] HLA and HIV-1:: Heterozygote advantage and B*35-Cw*04 disadvantage
    Carrington, M
    Nelson, GW
    Martin, MP
    Kissner, T
    Vlahov, D
    Goedert, JJ
    Kaslow, R
    Buchbinder, S
    Hoots, K
    O'Brien, SJ
    [J]. SCIENCE, 1999, 283 (5408) : 1748 - 1752
  • [10] Cavrois M, 1996, ONCOGENE, V12, P2419
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