Recyclization of 3-formylchromone with phenacyl thiocyanate: fast and efficient access to thiophenes and 2-aminothiophenes bearing o-acylphenol moiety

被引：9
作者：
Alizadeh, Abdolali [1 ]
Rezaiyehraad, Reza [1 ]
机构：
[1] Tarbiat Modares Univ, Dept Chem, POB 14115-175, Tehran, Iran
来源：
JOURNAL OF SULFUR CHEMISTRY | 2022年 / 43卷 / 03期
关键词：
O-Acylphenol skeleton; 3-formylchromone; phenacyl thiocyanate; thiophene; 2-aminothiophene; FRIES REARRANGEMENT; ONE-POT; BOND; DERIVATIVES; FUNCTIONALIZATION; SCAFFOLD; DESIGN;
D O I：
10.1080/17415993.2021.2007920
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A variety of substituted derivatives of thiophene and 2-aminothiophene bearing o-acylphenol moieties were obtained via the reaction between 3-formylchromone with phenacyl thiocyanate in the presence of Et3N. This metal-free procedure for the synthesis of thiophene skeletons revealed a good efficiency, higher diversity, and wide substrate tolerance. These compounds have structural similarities to biologically active compounds reported in the literature. Besides, they can be used as a suitable candidate for the synthesis of fused-thiophene heterocycles through C-H activation processes.
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收藏
页码：264 / 274
页数：11
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