The first chemical synthesis of boronic acid-modified DNA through a copper-free click reaction

被引：25
|
作者：
Dai, Chaofeng
Wang, Lifang
Sheng, Jia
Peng, Hanjing
Draganov, Alexander Boryanov
Huang, Zhen
Wang, Binghe [1 ]
机构：
[1] Georgia State Univ, Dept Chem, Atlanta, GA 30302 USA
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 12期
基金：
美国国家卫生研究院;
关键词：
CYCLOADDITION REACTION; TERMINAL ALKYNES; CHEMISTRY; DESIGN; AZIDES;
D O I：
10.1039/c0cc04546b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first chemical incorporation of the boronic acid group into DNA using a copper-free click reagent was reported. Compared with the PCR-based method, this approach allows for site-specific incorporation and synthesis on a larger scale.
引用
收藏
页码：3598 / 3600
页数：3
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