The Clinical Effects of Febuxostat Alone or Combined with Arthroscopic Surgery for Gout: A Single-Center Retrospective Study

被引:13
作者
Gong, Zhen [1 ]
Xia, Li [1 ]
Xu, Rune [1 ]
Luo, Min [1 ]
Deng, Hongxiang [1 ]
Kang, Zhiping [1 ]
Liu, Leping [1 ]
Liu, Yaqing [1 ]
Zhang, Fangjie [2 ]
Shi, Jian [1 ]
机构
[1] Yiyang Cent Hosp, Dept Rheumatol, 118 Kangfu North Rd, Yiyang 413000, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Dept Emergency Med, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China
基金
中国国家自然科学基金;
关键词
arthroscopy; febuxostat; crystal deposition; tophi; gout; XANTHINE-OXIDASE INHIBITORS; AMERICAN-COLLEGE; HYPERURICEMIA; MANAGEMENT;
D O I
10.2147/JIR.S329800
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Purpose: The purpose of the study was to retrospectively analyze the effects of febuxostat combined with arthroscopic debridement of monosodium urate crystal deposition and febuxostat treatment alone on uric acid levels and acute flares in gout patients. Patients and Methods: We retrospectively analyzed gout patients who were treated from February 2016 to December 2020. Patients were divided into a control group (febuxostat treatment alone) or a combined group (febuxostat combined with arthroscopic surgery). We recorded and analyzed clinical data including age, sex, body mass index, comorbidities, lesion affected joints, acute flare times, medications history, febuxostat side effects, arthro-scopic complications, and serum creatinine and uric acid levels changes. Results: There were 80 patients in the control group and 93 patients in the combined group. At the beginning of treatment, the combined group had significantly higher disease severity (higher serum uric acid levels and more acute gout flare times). Arthroscopy was performed in 61 knees and 38 ankles, and 86 joints showed crystals deposition. Compared with baseline, follow-up results showed that serum creatinine significantly decreased in the combined group, and serum uric acid and acute gout flare times significantly decreased in both groups (all p < 0.05). In the comparison between the two groups at the follow-up endpoint, acute gout flare times did not differ significantly (p > 0.05), however, serum creatinine and uric acid levels were lower in the combined group compared with those in the control group (ps < 0.05). Conclusion: Febuxostat combined with arthroscopic debridement of monosodium urate crystal deposition or tophi had a superior effect on lowering uric acid levels and acute flare times in gout patients than did febuxostat alone.
引用
收藏
页码:4509 / 4517
页数:9
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