The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma

被引：55

作者：

Brouwer, R ^{[1
]}

Pruijn, GJM ^{[1
]}

van Venrooij, WJ ^{[1
]}

机构：

[1] Univ Nijmegen, Dept Biochem, NL-6500 HB Nijmegen, Netherlands

来源：

ARTHRITIS RESEARCH | 2001年 / 3卷 / 02期

关键词：

autoantibodies; autoantigens; exoribonucleases; exosome; PM/Scl complex;

D O I：

10.1186/ar147

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75. These autoantigens have been reported to associate into a large complex consisting of 11 to 16 proteins and to play a role in ribosome synthesis. Recently, it was discovered that the PM/Scl complex is the human counterpart of the yeast (Saccharomyces cerevisiae) exosome, which is an RNA-processing complex consisting of 11 3'-->5' exoribonucleases. To date, 10 human exosome components have been identified, although only some of these were studied in more detail. In this review, we discuss some recent advances in the characterization of the PM/Scl complex.

引用

页码：102 / 106

页数：5

共 51 条

[41] Schnitz W, 1996, J RHEUMATOL, V23, P1729
[42] Shiomi T, 1998, J BIOCHEM-TOKYO, V123, P883
[43] NUCLEOLAR LOCALIZATION OF THE PM-SC1 ANTIGEN
TARGOFF, IN
REICHLIN, M
[J]. ARTHRITIS AND RHEUMATISM, 1985, 28 (02): : 226 - 230
[44] Yeast exosome mutants accumulate 3′-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs
Van Hoof, A
Lennertz, P
Parker, R
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (02) : 441 - 452
[45] The exosome: A proteasome for RNA?
van Hoof, A
Parker, R
[J]. CELL, 1999, 99 (04) : 347 - 350
[46] Ribosome synthesis in Saccharomyces cerevisiae
Venema, J
Tollervey, D
[J]. ANNUAL REVIEW OF GENETICS, 1999, 33 : 261 - 311
[47] AUTOANTIBODIES IN THE DIAGNOSIS OF SYSTEMIC RHEUMATIC DISEASES
VONMUHLEN, CA
TAN, EM
[J]. SEMINARS IN ARTHRITIS AND RHEUMATISM, 1995, 24 (05) : 323 - 358
[48] Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth
Williams, JM
Chen, GC
Zhu, L
Rest, RF
[J]. MOLECULAR MICROBIOLOGY, 1998, 27 (01) : 171 - 186
[49] ANTINUCLEAR ANTIBODY WITH DISTINCT SPECIFICITY FOR POLYMYOSITIS
WOLFE, JF
ADELSTEIN, E
SHARP, GC
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1977, 59 (01) : 176 - 178
[50] The exosome subunit Rrp43p is required for the efficient maturation of 5.8S, 18S and 25S rRNA
Zanchin, NIT
Goldfarb, DS
[J]. NUCLEIC ACIDS RESEARCH, 1999, 27 (05) : 1283 - 1288

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