The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma

被引：55
作者：
Brouwer, R [1 ]
Pruijn, GJM [1 ]
van Venrooij, WJ [1 ]
机构：
[1] Univ Nijmegen, Dept Biochem, NL-6500 HB Nijmegen, Netherlands
来源：
ARTHRITIS RESEARCH | 2001年 / 3卷 / 02期
关键词：
autoantibodies; autoantigens; exoribonucleases; exosome; PM/Scl complex;
D O I：
10.1186/ar147
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75. These autoantigens have been reported to associate into a large complex consisting of 11 to 16 proteins and to play a role in ribosome synthesis. Recently, it was discovered that the PM/Scl complex is the human counterpart of the yeast (Saccharomyces cerevisiae) exosome, which is an RNA-processing complex consisting of 11 3'-->5' exoribonucleases. To date, 10 human exosome components have been identified, although only some of these were studied in more detail. In this review, we discuss some recent advances in the characterization of the PM/Scl complex.
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页码：102 / 106
页数：5
相关论文
共 51 条
  • [11] Identification of a regulated pathway for nuclear pre-mRNA turnover
    Bousquet-Antonelli, C
    Presutti, C
    Tollervey, D
    [J]. CELL, 2000, 102 (06) : 765 - 775
  • [12] Rrp6p, the yeast homologue of the human PM-Scl 100-kDa autoantigen, is essential for efficient 5.8 S rRNA 3′ end formation
    Briggs, MW
    Burkard, KTD
    Butler, JS
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (21) : 13255 - 13263
  • [13] BROUWER R, 2001, IN PRESS J BIOL CHEM
  • [14] BROUWER R, 2001, IN PRESS ANN RHEUM D
  • [15] A nuclear 3′-5′ exonuclease involved in mRNA degradation interacts with poly(A) polymerase and the hnRNA protein Npl3p
    Burkard, KTD
    Butler, JS
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (02) : 604 - 616
  • [16] To be or not to be in the nucleolus
    Carmo-Fonseca, M
    Mendes-Soares, L
    Campos, I
    [J]. NATURE CELL BIOLOGY, 2000, 2 (06) : E107 - E112
  • [17] GE O, 1992, J CLIN INVEST, V90, P559
  • [18] ANALYSIS OF THE SPECIFICITY OF ANTI-PM-SCL AUTOANTIBODIES
    GE, Q
    WU, YJ
    TRIEU, EP
    TARGOFF, IN
    [J]. ARTHRITIS AND RHEUMATISM, 1994, 37 (10): : 1445 - 1452
  • [19] GELPI C, 1990, CLIN EXP IMMUNOL, V81, P59
  • [20] IMMUNOGENETIC ASSOCIATIONS OF SCLERODERMA-RELATED ANTINUCLEAR ANTIBODIES
    GENTH, E
    MIERAU, R
    GENETZKY, P
    VONMUHLEN, CA
    KAUFMANN, S
    VONWILMOWSKY, H
    MEURER, M
    KRIEG, T
    POLLMANN, HJ
    HARTL, PW
    [J]. ARTHRITIS AND RHEUMATISM, 1990, 33 (05): : 657 - 665
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