Hydroxylations and methylations of quercetin, fisetin, and catechin by Streptomyces griseus

被引：53
作者：
Hosny, M [1 ]
Dhar, K [1 ]
Rosazza, JPN [1 ]
机构：
[1] Univ Iowa, Coll Pharm, Div Med & Nat Prod Chem, Ctr Biocatalysis & Bioproc, Iowa City, IA 52242 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 04期
关键词：
D O I：
10.1021/np000457m
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Preparative-scale biotransformation of quercetin (1), fisetin (7), and (+)-catechin (12) with Streptomyces griseus (ATCC 13273) resulted in the isolation and characterization of nine known hydroxylated and/or methylated (2-6, 8, 9, 11, 13a) metabolites and two previously unknown (10 and 14) metabolites. S. griseus catalyzed aromatic hydroxylations of rings A and B of quercetin and fisetin. Mono- and dimethoxy ring-B metabolites were obtained with all three substrates. Methylation appeared to occur only when catechol functional groups were present. Metabolite structures were established by FABMS, EIMS, and 1D and 2D NMR analysis.
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页码：462 / 465
页数：4
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