Hydrogen sulfide: an old gas with new cardioprotective effects

被引：9
|
作者：
Patel, Vaibhav B. [1 ,2 ]
McLean, Brent A. [2 ,3 ]
Chen, Xueyi [1 ,2 ]
Oudit, Gavin Y. [1 ,2 ,3 ]
机构：
[1] Univ Alberta, Dept Med, Div Cardiol, Edmonton, AB, Canada
[2] Univ Alberta, Mazankowski Alberta Heart Inst, Edmonton, AB, Canada
[3] Univ Alberta, Dept Physiol, Edmonton, AB, Canada
来源：
CLINICAL SCIENCE | 2015年 / 128卷 / 05期
基金：
加拿大健康研究院;
关键词：
apoptosis; diabetic cardiomyopathy; hydrogen sulfide; inflammation; oxidative stress; DIABETIC CARDIOVASCULAR COMPLICATIONS; NITRIC-OXIDE SYNTHASE; HEART-FAILURE; DYSFUNCTION; RATS;
D O I：
10.1042/CS20140668
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Diabetic cardiovascular complications are reaching epidemic proportions and the risk of HF (heart failure) is increased 2-3-fold by diabetes mellitus. H2S (hydrogen sulfide) is emerging as a new gaseous signalling molecule in the cardiovascular system which possesses multifactorial effects on various intracellular signalling pathways. The proven cardioprotective and vasodilator activities of H2S warrant a detailed investigation into its role in diabetic cardiomyopathy. In the present issue of Clinical Science, Zhou et al. demonstrate an important therapeutic potential of the H2S pathway in diabetic cardiomyopathy.
引用
收藏
页码：321 / 323
页数：3
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