A Parallel Screen for the Discovery of Novel DNA Base Pairs

被引：6

作者：

Yaren, Oezlem ^{[1
]}

Mosimann, Markus ^{[1
]}

Leumann, Christian J. ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, Freiestr 3, CH-3012 Bern, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 08期

基金：

瑞士国家科学基金会;

关键词：

combinatorial chemistry; DNA recognition; fluorescent probes; nucleosides; parallel synthesis; SITE-SPECIFIC INCORPORATION; GENETIC ALPHABET; CARBOCYCLIC NUCLEOSIDES; ENZYMATIC INCORPORATION; RNA; SYSTEMS; OLIGONUCLEOTIDES; RESCUE; TRANSCRIPTION; REPLICATION;

D O I：

10.1002/anie.201005300

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Speed dating: A combinatorial assay was developed for screening a library of aromatic heterocyclic amines for their propensity to act as a complementary base Z in a DNA duplex. This assay may prove useful in speeding up the process of base-pair discovery for potential applications in biotechnology and synthetic biology. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1935 / 1938

页数：4

共 31 条

[1] THE EVALUATION OF 2'-SUBSTITUTED AND 6'-SUBSTITUTED CARBOCYCLIC NUCLEOSIDES AS BUILDING-BLOCKS FOR ANTISENSE OLIGONUCLEOTIDES [J].

ALTMANN, KH ;

BEVIERRE, MO ;

DEMESMAEKER, A ;

MOSER, HE .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (05) :431-436

[2] Synthesis of novel 3′-C-methylene thymidine and 5-methyluridine/cytidine H-phosphonates and phosphonamidites for new backbone modification of oligonucleotides [J].

An, HY ;

Wang, TM ;

Maier, MA ;

Manoharan, M ;

Ross, BS ;

Cook, PD .

JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (08) :2789-2801

[3] RIBOSOME-MEDIATED INCORPORATION OF A NONSTANDARD AMINO-ACID INTO A PEPTIDE THROUGH EXPANSION OF THE GENETIC-CODE [J].

BAIN, JD ;

SWITZER, C ;

CHAMBERLIN, AR ;

BENNER, SA .

NATURE, 1992, 356 (6369) :537-539

[4]

Berger M, 2000, ANGEW CHEM INT EDIT, V39, P2940, DOI 10.1002/1521-3773(20000818)39:16<2940::AID-ANIE2940>3.0.CO

[5]

2-#

[6]

BERGER M, 2000, ANGEW CHEM, V112, P3069

[7] Beyond A, C, G and T: augmenting nature's alphabet [J].

Henry, AA ;

Romesberg, FE .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2003, 7 (06) :727-733

[8] An unnatural hydrophobic base pair system: site-specific incorporation of nucleotide analogs into DNA and RNA [J].

Hirao, Ichiro ;

Kimoto, Michiko ;

Mitsui, Tsuneo ;

Fujiwara, Tsuyoshi ;

Kawai, Rie ;

Sato, Akira ;

Harada, Yoko ;

Yokoyama, Shigeyuki .

NATURE METHODS, 2006, 3 (09) :729-735

[9]

Hoshika S., 2010, ANGEW CHEM, V722, P5686

[10] Artificial Genetic Systems: Self-Avoiding DNA in PCR and Multiplexed PCR [J].

Hoshika, Shuichi ;

Chen, Fei ;

Leal, Nicole A. ;

Benner, Steven A. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (32) :5554-5557

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