Modulating the Vascular Response to Limb Ischemia Angiogenic and Cell Therapies

被引:169
作者
Cooke, John P. [1 ]
Losordo, Douglas W. [2 ]
机构
[1] Houston Methodist Res Inst, Dept Cardiovasc Sci, 6670 Bertner Ave,Mail Stop R10 South, Houston, TX 77030 USA
[2] NeoStem Inc, New York, NY 10170 USA
基金
美国国家卫生研究院;
关键词
angiogenesis; genetic therapy; microvessels; progenitor cell; stem cells; vasculogenesis; ENDOTHELIAL PROGENITOR CELLS; PERIPHERAL ARTERIAL-DISEASE; HEPATOCYTE GROWTH-FACTOR; COLONY-STIMULATING FACTOR; MARROW-MONONUCLEAR-CELLS; PLACEBO-CONTROLLED TRIAL; MESENCHYMAL STEM-CELLS; PHASE-II MULTICENTER; MUSCLE BLOOD-FLOW; BONE-MARROW;
D O I
10.1161/CIRCRESAHA.115.303565
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The age-adjusted prevalence of peripheral arterial disease in the US population has been estimated to approach 12%. The clinical consequences of occlusive peripheral arterial disease include pain on walking (claudication), pain at rest, and loss of tissue integrity in the distal limbs; the latter may ultimately lead to amputation of a portion of the lower extremity. Surgical bypass techniques and percutaneous catheter-based interventions may successfully reperfuse the limbs of certain patients with peripheral arterial disease. In many patients, however, the anatomic extent and distribution of arterial occlusion is too severe to permit relief of pain and healing of ischemic ulcers. No effective medical therapy is available for the treatment of such patients, for many of whom amputation represents the only hope for alleviation of symptoms. The ultimate failure of medical treatment and procedural revascularization in significant numbers of patients has led to attempts to develop alternative therapies for ischemic disease. These strategies include administration of angiogenic cytokines, either as recombinant protein or as gene therapy, and more recently, to investigations of stem/progenitor cell therapy. The purpose of this review is to provide an outline of the preclinical basis for angiogenic and stem cell therapies, review the clinical research that has been done, summarize the lessons learned, identify gaps in knowledge, and suggest a course toward successfully addressing an unmet medical need in a large and growing patient population.
引用
收藏
页码:1561 / 1578
页数:18
相关论文
共 163 条
[81]   Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial [J].
Lederman, RJ ;
Mendelsohn, FO ;
Anderson, RD ;
Saucedo, JF ;
Tenaglia, AN ;
Hermiller, JB ;
Hillegass, WB ;
Rocha-Singh, K ;
Moon, TE ;
Whitehouse, MJ ;
Annex, BH .
LANCET, 2002, 359 (9323) :2053-2058
[82]   MicroRNA and Mechanisms of Impaired Angiogenesis in Diabetes Mellitus [J].
Leeper, Nicholas J. ;
Cooke, John P. .
CIRCULATION, 2011, 123 (03) :236-238
[83]   Therapeutical potential of blood-derived progenitor cells in patients with peripheral arterial occlusive disease and critical limb ischaemia [J].
Lenk, K ;
Adams, V ;
Lurz, P ;
Erbs, S ;
Linke, A ;
Gielen, S ;
Schmidt, A ;
Scheinert, D ;
Biamino, G ;
Emmrich, F ;
Schuler, G ;
Hambrecht, R .
EUROPEAN HEART JOURNAL, 2005, 26 (18) :1903-1909
[84]   Coronary vascular remodeling in association with endothelial dysfunction [J].
Lerman, A ;
Cannan, CR ;
Higano, SH ;
Nishimura, RA ;
Holmes, DR .
AMERICAN JOURNAL OF CARDIOLOGY, 1998, 81 (09) :1105-1109
[85]   Differentiation, survival, and function of embryonic stem cell-derived endothelial cells for ischemic heart disease [J].
Li, Zongjin ;
Wu, Jenny C. ;
Sheikh, Ahmad Y. ;
Kraft, Daniel ;
Cao, Feng ;
Xie, Xiaoyan ;
Patel, Manishkumar ;
Gambhir, Sanjiv S. ;
Robbins, Robert C. ;
Cooke, John P. ;
Wu, Joseph C. .
CIRCULATION, 2007, 116 (11) :I46-I54
[86]   Functional Mesenchymal Stem Cells Derived From Human Induced Pluripotent Stem Cells Attenuate Limb Ischemia in Mice [J].
Lian, Qizhou ;
Zhang, Yuelin ;
Zhang, Jinqiu ;
Zhang, Hua Kun ;
Wu, Xingang ;
Zhang, Yang ;
Lam, Francis Fu-Yuen ;
Kang, Sarang ;
Xia, Jian Chuan ;
Lai, Wing-Hong ;
Au, Ka-Wing ;
Chow, Yen Yen ;
Siu, Chung-Wah ;
Lee, Chuen-Neng ;
Tse, Hung-Fat .
CIRCULATION, 2010, 121 (09) :1113-U91
[87]   A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010 [J].
Lim, Stephen S. ;
Vos, Theo ;
Flaxman, Abraham D. ;
Danaei, Goodarz ;
Shibuya, Kenji ;
Adair-Rohani, Heather ;
Amann, Markus ;
Anderson, H. Ross ;
Andrews, Kathryn G. ;
Aryee, Martin ;
Atkinson, Charles ;
Bacchus, Loraine J. ;
Bahalim, Adil N. ;
Balakrishnan, Kalpana ;
Balmes, John ;
Barker-Collo, Suzanne ;
Baxter, Amanda ;
Bell, Michelle L. ;
Blore, Jed D. ;
Blyth, Fiona ;
Bonner, Carissa ;
Borges, Guilherme ;
Bourne, Rupert ;
Boussinesq, Michel ;
Brauer, Michael ;
Brooks, Peter ;
Bruce, Nigel G. ;
Brunekreef, Bert ;
Bryan-Hancock, Claire ;
Bucello, Chiara ;
Buchbinder, Rachelle ;
Bull, Fiona ;
Burnett, Richard T. ;
Byers, Tim E. ;
Calabria, Bianca ;
Carapetis, Jonathan ;
Carnahan, Emily ;
Chafe, Zoe ;
Charlson, Fiona ;
Chen, Honglei ;
Chen, Jian Shen ;
Cheng, Andrew Tai-Ann ;
Child, Jennifer Christine ;
Cohen, Aaron ;
Colson, K. Ellicott ;
Cowie, Benjamin C. ;
Darby, Sarah ;
Darling, Susan ;
Davis, Adrian ;
Degenhardt, Louisa .
LANCET, 2012, 380 (9859) :2224-2260
[88]   A Randomized, Controlled Pilot Study of Autologous CD34+ Cell Therapy for Critical Limb Ischemia [J].
Losordo, Douglas W. ;
Kibbe, Melina R. ;
Mendelsohn, Farrell ;
Marston, William ;
Driver, Vickie R. ;
Sharafuddin, Melhem ;
Teodorescu, Victoria ;
Wiechmann, Bret N. ;
Thompson, Charles ;
Kraiss, Larry ;
Carman, Teresa ;
Dohad, Suhail ;
Huang, Paul ;
Junge, Candice E. ;
Story, Kenneth ;
Weistroffer, Tara ;
Thorne, Tina M. ;
Millay, Meredith ;
Runyon, John Paul ;
Schainfeld, Robert .
CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 2012, 5 (06) :821-830
[89]  
Losordo DW, 2011, CIRCULATION, V124
[90]   Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: A double-blind, randomized, controlled trial [J].
Lu, Debin ;
Chen, Bing ;
Liang, Ziwen ;
Deng, Wuquan ;
Jiang, Youzhao ;
Li, Shufa ;
Xu, Jing ;
Wu, Qinan ;
Zhang, Zhonghui ;
Xie, Bing ;
Chen, Sihao .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2011, 92 (01) :26-36