Synthesis and antitumor activity of amine analogs of irofulven

被引：8
|
作者：
McMorris, Trevor C. [1 ]
Chimmani, Ramesh [1 ]
Gurram, Mahender [1 ]
Staake, Michael D. [1 ]
Kelner, Michael J. [2 ]
机构：
[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
[2] UCSD Med Ctr, Dept Pathol, San Diego, CA 92103 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 24期
关键词：
irofulven; analogs synthesis; staudinger ligation; reductive amination; antitumor activity;
D O I：
10.1016/j.bmcl.2007.10.040
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Acylfulvenes, a class of semisynthetic analogs of Illudin S, show high toxicity toward prostate cancer cells. Here we probe the effect of changes in hydrophilic character of the analogs. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6770 / 6772
页数：3
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