Anti-tumor and anti-carcinogenic activities of triterpenoid, β-boswellic acid

被引:93
|
作者
Huang, MT [1 ]
Badmaev, V
Ding, Y
Liu, Y
Xie, JG
Ho, CT
机构
[1] Rutgers State Univ, Coll Pharm, Canc Res Lab, Piscataway, NJ 08854 USA
[2] Sabinsa Corp, Piscataway, NJ 08854 USA
[3] Rutgers State Univ, Cook Coll, Dept Food Sci, Piscataway, NJ 08854 USA
关键词
Boswellin; triterpenoid; triterpene acid; boswellic acid; cancer prevention;
D O I
10.1002/biof.5520130135
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Boswellin (BE), a methanol extract of the gum resin exudate of Boswellia serrata, contains naturally occurring triterpenoids, beta -boswellic acid and its structural related derivatives, has been used as a traditional medicine for the treatment of inflammatory and arthritic diseases. Topical application of BE to the backs of mice markedly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in skin inflammation, epidermal proliferation, the number of epidermal cell layers, and tumor promotion in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated mice. Feeding 0.2% of BE in the diet to CF-1 mice for 10-24 weeks reduced the accumulation of parametrial fat pad weight under the abdomen, and inhibited azoxymethane (AOM)-induced formation of aberrant crypt foci (ACF) by 46%. Addition of pure beta -boswellic acid, 3-O-acetyl-beta -boswellic acid, 11-keto-beta -boswellic acid or 3-O-acetyl-11-keto-beta -boswellic acid (Fig. 1)to human leukemia HL-60 cell culture inhibited DNA synthesis in HL-60 cells in a dose-dependent manner with IC50 values ranging from 0.6 to 7.1 muM These results indicate that beta -boswellic acid and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities.
引用
收藏
页码:225 / 230
页数:6
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