The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application

被引：23
作者：
Aili, Yirizhati [1 ]
Maimaitiming, Nuersimanguli [2 ]
Mahemuti, Yusufu [1 ]
Qin, Hu [1 ]
Wang, Yongxin [1 ]
Wang, Zengliang [1 ]
机构：
[1] Xinjiang Med Univ, Dept Neurosurg, Affiliated Hosp 1, Xinjiang, Peoples R China
[2] Xinjiang Med Univ, Dept Oncol, Affiliated Hosp 1, Xinjiang, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
关键词：
glioma; exosomes; miRNA; microenvironment; biomarkers; MESENCHYMAL STEM-CELLS; EXTRACELLULAR VESICLES; PROGNOSTIC BIOMARKER; EXPRESSION PROFILE; ENDOTHELIAL-CELLS; POOR-PROGNOSIS; GLIOBLASTOMA; PROLIFERATION; MIGRATION; SERUM;
D O I：
10.3389/fonc.2021.686369
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gliomas are complex and heterogeneous central nervous system tumors with poor prognosis. Despite the increasing development of aggressive combination therapies, the prognosis of glioma is generally unsatisfactory. Exosomal microRNA (miRNA) has been successfully used in other diseases as a reliable biomarker and even therapeutic target. Recent studies show that exosomal miRNA plays an important role in glioma occurrence, development, invasion, metastasis, and treatment resistance. However, the association of exosomal miRNA between glioma has not been systemically characterized. This will provide a theoretical basis for us to further explore the relationship between exosomal miRNAs and glioma and also has a positive clinical significance in the innovative diagnosis and treatment of glioma.
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页数：15
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