The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application

被引：23

作者：

Aili, Yirizhati ^{[1
]}

Maimaitiming, Nuersimanguli ^{[2
]}

Mahemuti, Yusufu ^{[1
]}

Qin, Hu ^{[1
]}

Wang, Yongxin ^{[1
]}

Wang, Zengliang ^{[1
]}

机构：

[1] Xinjiang Med Univ, Dept Neurosurg, Affiliated Hosp 1, Xinjiang, Peoples R China

[2] Xinjiang Med Univ, Dept Oncol, Affiliated Hosp 1, Xinjiang, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

关键词：

glioma; exosomes; miRNA; microenvironment; biomarkers; MESENCHYMAL STEM-CELLS; EXTRACELLULAR VESICLES; PROGNOSTIC BIOMARKER; EXPRESSION PROFILE; ENDOTHELIAL-CELLS; POOR-PROGNOSIS; GLIOBLASTOMA; PROLIFERATION; MIGRATION; SERUM;

D O I：

10.3389/fonc.2021.686369

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gliomas are complex and heterogeneous central nervous system tumors with poor prognosis. Despite the increasing development of aggressive combination therapies, the prognosis of glioma is generally unsatisfactory. Exosomal microRNA (miRNA) has been successfully used in other diseases as a reliable biomarker and even therapeutic target. Recent studies show that exosomal miRNA plays an important role in glioma occurrence, development, invasion, metastasis, and treatment resistance. However, the association of exosomal miRNA between glioma has not been systemically characterized. This will provide a theoretical basis for us to further explore the relationship between exosomal miRNAs and glioma and also has a positive clinical significance in the innovative diagnosis and treatment of glioma.

引用

页数：15

共 111 条

[1] Low glucose availability alters the expression of genes involved in initial adhesion of human glioblastoma cancer cell line SF767 [J].

Aftab, Saira ;

Shakoori, Abdul Rauf .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (10) :16824-16839

[2] Glucose-Based Regulation of miR-451/AMPK Signaling Depends on the OCT1 Transcription Factor [J].

Ansari, Khairul I. ;

Ogawa, Daisuke ;

Rooj, Arun K. ;

Lawler, Sean E. ;

Krichevsky, Anna M. ;

Johnson, Mark D. ;

Chiocca, E. Antonio ;

Bronisz, Agnieszka ;

Godlewski, Jakub .

CELL REPORTS, 2015, 11 (06) :902-909

[3] Exosomes and autoplagy: coordinated mechanisms for the maintenance of cellular fitness [J].

Baixauli, Francesc ;

Lopez-Otin, Carlos ;

Mittelbrunn, Maria .

FRONTIERS IN IMMUNOLOGY, 2014, 5

[4] Exosomes: Therapy delivery tools and biomarkers of diseases [J].

Barile, Lucio ;

Vassalli, Giuseppe .

PHARMACOLOGY & THERAPEUTICS, 2017, 174 :63-78

[5] Longitudinal molecular trajectories of diffuse glioma in adults [J].

Barthel, Floris P. ;

Johnson, Kevin C. ;

Varn, Frederick S. ;

Moskalik, Anzhela D. ;

Tanner, Georgette ;

Kocakavuk, Emre ;

Anderson, Kevin J. ;

Abiola, Olajide ;

Aldape, Kenneth ;

Alfaro, Kristin D. ;

Alpar, Donat ;

Amin, Samirkumar B. ;

Ashley, David M. ;

Bandopadhayay, Pratiti ;

Barnholtz-Sloan, Jill S. ;

Beroukhim, Rameen ;

Bock, Christoph ;

Brastianos, Priscilla K. ;

Brat, Daniel J. ;

Brodbelt, Andrew R. ;

Bruns, Alexander F. ;

Bulsara, Ketan R. ;

Chakrabarty, Aruna ;

Chakravarti, Arnab ;

Chuang, Jeffrey H. ;

Claus, Elizabeth B. ;

Cochran, Elizabeth J. ;

Connelly, Jennifer ;

Costello, Joseph F. ;

Finocchiaro, Gaetano ;

Fletcher, Michael N. ;

French, Pim J. ;

Gan, Hui K. ;

Gilbert, Mark R. ;

Gould, Peter V. ;

Grimmer, Matthew R. ;

Iavarone, Antonio ;

Ismail, Azzam ;

Jenkinson, Michael D. ;

Khasraw, Mustafa ;

Kim, Hoon ;

Kouwenhoven, Mathilde C. M. ;

LaViolette, Peter S. ;

Li, Meihong ;

Lichter, Peter ;

Ligon, Keith L. ;

Lowman, Allison K. ;

Malta, Tathiane M. ;

Mazor, Tali ;

McDonald, Kerrie L. .

NATURE, 2019, 576 (7785) :112-+

[6] Extracellular Vesicles in Glioma: From Diagnosis to Therapy [J].

Basu, Bhaskar ;

Ghosh, Mrinal K. .

BIOESSAYS, 2019, 41 (07)

[7] Exosomal Chaperones and miRNAs in Gliomagenesis: State-of-Art and Theranostics Perspectives [J].

Bavisotto, Celeste Caruso ;

Graziano, Francesca ;

Rappa, Francesca ;

Gammazza, Antonella Marino ;

Logozzi, Mariantonia ;

Fais, Stefano ;

Maugeri, Rosario ;

Bucchieri, Fabio ;

de Macario, Everly Conway ;

Macario, Alberto J. L. ;

Cappello, Francesco ;

Iacopino, Domenico G. ;

Campanella, Claudia .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (09)

[8] Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1 [J].

Bronisz, Agnieszka ;

Wang, Yan ;

Nowicki, Michal O. ;

Peruzzi, Pierpaolo ;

Ansari, Khairul I. ;

Ogawa, Daisuke ;

Balaj, Leonora ;

De Rienzo, Gianluca ;

Mineo, Marco ;

Nakano, Ichiro ;

Ostrowski, Michael C. ;

Hochberg, Fred ;

Weissleder, Ralph ;

Lawler, Sean E. ;

Chiocca, E. Antonio ;

Godlewski, Jakub .

CANCER RESEARCH, 2014, 74 (03) :738-750

[9] The Roles of miRNA in Glioblastoma Tumor Cell Communication: Diplomatic and Aggressive Negotiations [J].

Buruiana, Andrei ;

Florian, Stefan Ioan ;

Florian, Alexandru Ioan ;

Timis, Teodora-Larisa ;

Mihu, Carmen Mihaela ;

Miclaus, Maria ;

Osan, Sergiu ;

Hrapsa, Iona ;

Cataniciu, Radu Constantin ;

Farcas, Marius ;

Susman, Sergiu .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (06)

[10] Exosomes of glioma cells deliver miR-148a to promote proliferation and metastasis of glioblastoma via targeting CADM1 [J].

Cai, Qian ;

Zhu, Anding ;

Gong, Li .

BULLETIN DU CANCER, 2018, 105 (7-8) :643-651

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