Two new lignans with their biological activities in Portulaca oleracea L.

被引：7
|
作者：
Wang, Chengyu [1 ]
Guo, Shengnan [1 ]
Tian, Jiayin [1 ]
Liu, Peishan [1 ]
Song, Mingyang [1 ]
Zhang, Wenjie [1 ,2 ]
Ying, Xixiang [1 ,2 ]
机构：
[1] Liaoning Univ Tradit Chinese Med, Sch Pharm, Dalian, Peoples R China
[2] Liaoning Univ Tradit Chinese Med, Sch Pharm, 77, Shengming 1 Rd, DD Port, Dalian 116600, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2022年 / 50卷
基金：
中国国家自然科学基金;
关键词：
Portulaca oleracea L; Oleralignan; Lignan; Anti-inflammatory activity; Antioxidant activity; POLYSACCHARIDE; CELLS;
D O I：
10.1016/j.phytol.2022.06.003
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new lignans, identified as 6,7-dihydroxy-4-(4 ''-hydroxy-3 ''-methoxyphenyl)-2-naphthoic acid, named Oleralignan C (1), and 4-(3,4-dihydroxyphenyl)-6-hydroxy-7-methoxy-2-naphthoic acid, named Oleralignan D (2), were obtained from Portulaca oleracea L. The structures were determined by spectroscopic methods, including UHPLC-ESI-QTOFMS, D-1 and D-2 NMR. Both Oleralignan C (1) and Oleralignan D (2) inhibited the inflammatory factors, IL-1 beta and TNF-alpha in RAW 264.7 cells induced by lipopolysaccharide (LPS). Both compounds also could clear 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radicals indicating their antioxidant potential.
引用
收藏
页码：95 / 99
页数：5
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