One-pot three-component protocol for the synthesis of substituted 2-aminothiazoles

被引：7
|
作者：
Guo, Shanshan [1 ]
Zhao, Donghong [1 ]
Zhu, Yue [1 ]
Yu, Yongping [1 ]
Chen, Wenteng [1 ]
Zhang, Guolin [1 ]
机构：
[1] Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Zhejiang, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2017年 / 47卷 / 19期
基金：
中国国家自然科学基金;
关键词：
2-Aminothiazoles; -nitro-epoxides; cyanamide; multicomponent; sodium sulfide; DERIVATIVES; THIAZOLES; KETONES; IMIDAZOPYRIDINES; ISOTHIOCYANATES; INHIBITORS; THIOUREAS; STRATEGY; DESIGN; AGENTS;
D O I：
10.1080/00397911.2017.1350275
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Substituted 2-aminothiazoles have been synthesized from -nitro-epoxides, cyanamide, and sodium sulfide through a facile, three-component, and ecofriendly protocol with good to excellent yields. This reaction was achieved at room temperature without any additives. A possible mechanism has also been proposed. [GRAPHICS] .
引用
收藏
页码：1758 / 1764
页数：7
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