One-pot three-component protocol for the synthesis of substituted 2-aminothiazoles

被引：7

作者：

Guo, Shanshan ^{[1
]}

Zhao, Donghong ^{[1
]}

Zhu, Yue ^{[1
]}

Yu, Yongping ^{[1
]}

Chen, Wenteng ^{[1
]}

Zhang, Guolin ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Zhejiang, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2017年 / 47卷 / 19期

基金：

中国国家自然科学基金;

关键词：

2-Aminothiazoles; -nitro-epoxides; cyanamide; multicomponent; sodium sulfide; DERIVATIVES; THIAZOLES; KETONES; IMIDAZOPYRIDINES; ISOTHIOCYANATES; INHIBITORS; THIOUREAS; STRATEGY; DESIGN; AGENTS;

D O I：

10.1080/00397911.2017.1350275

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substituted 2-aminothiazoles have been synthesized from -nitro-epoxides, cyanamide, and sodium sulfide through a facile, three-component, and ecofriendly protocol with good to excellent yields. This reaction was achieved at room temperature without any additives. A possible mechanism has also been proposed. [GRAPHICS] .

引用

页码：1758 / 1764

页数：7

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