L-α-phosphatidyl-D-myo-inositol 3,5-bisphosphate:: total synthesis of a new inositol phospholipid via myo-inositol orthoacetate

被引：22
|
作者：
Riley, AM [1 ]
Potter, BVL [1 ]
机构：
[1] Univ Bath, Dept Pharm & Pharmacol, Wolfson Lab Med Chem, Bath BA2 7AY, Avon, England
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 37期
关键词：
D O I：
10.1016/S0040-4039(98)01422-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis from myo-inositol of a newly-discovered inositol phospholipid, phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P-2], is described. The synthetic strategy, employing inter alia, a trimethylaluminium-mediated regioselective cleavage of a protected inyo-inositol orthoacetate followed by an optical resolution using (R)-(-)-5-oxo-2-tetrahydrofurancarboxylate esters, allows rapid access to dipalmitoyl PtdIns(3,5)P-2. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：6769 / 6772
页数：4
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