Effect of Hyperbaric Oxygen on the Anticancer Effect of Artemisinin on Molt-4 Human Leukemia Cells

被引：1

作者：

Ohgami, Yusuke ^{[1
]}

Elstad, Catherine A. ^{[1
]}

Chung, Eunhee ^{[1
]}

Shirachi, Donald Y. ^{[3
]}

Quock, Raymond M. ^{[1
]}

Lai, Henry C. ^{[2
]}

机构：

[1] Washington State Univ, Coll Pharm, Dept Pharmaceut Sci, Pullman, WA 99164 USA

[2] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[3] Chico Hyperbar Ctr, Chico, CA 95926 USA

来源：

ANTICANCER RESEARCH | 2010年 / 30卷 / 11期

关键词：

Anticancer complementary therapy; oxygen tension; Artemisinin; chemotherapy; hyperbaric oxygen; leukemia cells; CANCER-CELLS; PROSTATE-CANCER; DIHYDROARTEMISININ; APOPTOSIS; INHIBITION; ARTESUNATE; GROWTH; HOLOTRANSFERRIN; PROLIFERATION; CYTOTOXICITY;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Artemisinin selectively kills cancer cells which have more intracellular free iron than do normal cells. Hyperbaric oxygen (HBO2) may be beneficial in the treatment of cancer. The hypothesis of this study was that HBO2 enhances anticancer activity of artemisinin. Materials and Methods: After pretreatment with 12 mu M holotransferrin, Molt-4 human leukemia cells were cultured in 10 mu M artemisinin and exposed for 90 min to one of three different conditions: control, room air control, and HBO2. Cell growth was determined for 48 h after exposure. Results: Differences in growth were noted after 6 h of incubation. After 48 h of incubation, growth of cells treated with artemisinin alone or HBO2 alone was 85% of that of cells grown under artemisinin-free control conditions. Combined artemisinin and HBO2 treatment resulted in an additional 22% decrease in growth. Conclusion: Combined HBO2 and artemisinin exposure may be an effective anticancer chemotherapeutic strategy.

引用

页码：4467 / 4470

页数：4

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