trans-Platinum(II) complex of 3-aminoflavone - synthesis, X-ray crystal structure and biological activities in vitro

被引：13

作者：

Fabijanska, Malgorzata ^{[1
]}

Studzian, Kazimierz ^{[2
]}

Szmigiero, Leszek ^{[2
]}

Rybarczyk-Pirek, Agnieszka J. ^{[3
]}

Pfitzner, Arno ^{[4
]}

Cebula-Obrzut, Barbara ^{[5
]}

Smolewski, Piotr ^{[5
]}

Zyner, Elzbieta ^{[1
]}

Ochocki, Justyn ^{[1
]}

机构：

[1] Med Univ Lodz, Dept Bioinorgan Chem, PL-90151 Lodz, Poland

[2] Med Univ Lodz, Dept Nucle Acids Biochem, PL-92215 Lodz, Poland

[3] Univ Lodz, Struct Chem & Crystallog Grp, Dept Theoret & Struct Chem, PL-90236 Lodz, Poland

[4] Univ Regensburg, Inst Anorgan Chem, D-93053 Regensburg, Germany

[5] Med Univ Lodz, Dept Expt Hematol, PL-93510 Lodz, Poland

来源：

DALTON TRANSACTIONS | 2015年 / 44卷 / 03期

关键词：

SULFONAMIDE PLATINUM COMPLEXES; CIS-PT(II) COMPLEX; CIS-DDP; HYDROGEN-BONDS; A549; CELLS; GENOTOXICITY; DERIVATIVES; INDUCTION; APOPTOSIS; NECROSIS;

D O I：

10.1039/c4dt01501k

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This paper describes the synthesis of trans-bis-(3-aminoflavone)dichloridoplatinum(II) (trans-Pt(3-af)(2)Cl-2; TCAP) for use as a potential anticancer compound, and the evaluation of its structure by elemental and spectral analyses, and X-ray crystallography. The complex demonstrated a significant cytotoxic effect against human and murine cancer cell lines, as well as weaker toxicity towards healthy cells (human peripheral blood lymphocytes) in comparison with cisplatin. Various biochemical and morphological methods confirm that the proapoptotic activity of trans-Pt(3-af)(2)Cl-2 is markedly higher than the reference cisplatin. Our results suggest that trans-Pt(3-af)(2)Cl-2 may have a different antitumour specificity from that of cisplatin.

引用

页码：938 / 947

页数：10

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