CST Meets Shelterin to Keep Telomeres in Check

被引：115
作者：
Giraud-Panis, Marie-Josephe [1 ,2 ,3 ]
Teixeira, M. Teresa [3 ]
Geli, Vincent [4 ]
Gilson, Eric [1 ,2 ,3 ,5 ]
机构：
[1] Univ Nice, Lab Biol & Pathol Genomes, CNRS, INSERM,UMR 6267,U998,Fac Med, F-06107 Nice 2, France
[2] Univ Lyon, Lab Joliot Curie, Ecole Normale Super Lyon, F-69364 Lyon, France
[3] Univ Lyon, Lab Biol Mol Cellule, Ecole Normale Super Lyon, CNRS,UMR 5239, F-69364 Lyon, France
[4] CNRS, Instabilite Genome & Cancerogenese, CNRS, F-13402 Marseille 20, France
[5] Ctr Hosp Univ Nice, Dept Med Genet, Archet Hosp 2, F-06202 Nice, France
来源：
MOLECULAR CELL | 2010年 / 39卷 / 05期
关键词：
SINGLE-STRANDED-DNA; CHROMOSOME END-PROTECTION; POLYMERASE-ALPHA-PRIMASE; SACCHAROMYCES-CEREVISIAE; BINDING-PROTEIN; YEAST TELOMERASE; OB-FOLD; LENGTH REGULATION; MAMMALIAN TELOMERES; ACCESSORY PROTEIN;
D O I：
10.1016/j.molcel.2010.08.024
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Telomere protection in budding yeast requires the heterotrimer named CST (for Cdc13-Stn1-Ten1). Recent data show that CST components are conserved and required for telomere stability in a wide range of eukaryotes, even those utilizing the shelterin complex to protect their telomeres. A common function of these proteins might be to stimulate priming at the C-strand gap that remains after telomerase elongation, replication termination, and terminal processing. In light of the budding yeast situation, another conserved function of CST might well be the regulation of telomerase. The cohabitation at telomeres of CST and shelterin components highlights the complexity of telomere biology.
引用
收藏
页码：665 / 676
页数：12
相关论文
共 98 条
  • [51] Progressive cis-inhibition of telomerase upon telomere elongation
    Marcand, S
    Brevet, V
    Gilson, E
    [J]. EMBO JOURNAL, 1999, 18 (12) : 3509 - 3519
  • [52] EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Δ mutants
    Maringele, L
    Lydall, D
    [J]. GENES & DEVELOPMENT, 2002, 16 (15) : 1919 - 1933
  • [53] Protection of telomeres by a conserved Stn1-Ten1 complex
    Martin, Victoria
    Du, Li-Lin
    Rozenzhak, Sophie
    Russell, Paul
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (35) : 14038 - 14043
  • [54] Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA
    Mer, G
    Bochkarev, A
    Gupta, R
    Bochkareva, E
    Frappier, L
    Ingles, CJ
    Edwards, AM
    Chazin, WJ
    [J]. CELL, 2000, 103 (03) : 449 - 456
  • [55] Semi-conservative DNA replication through telomeres requires Taz1
    Miller, KM
    Rog, O
    Cooper, JP
    [J]. NATURE, 2006, 440 (7085) : 824 - 828
  • [56] Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
    Mimitou, Eleni P.
    Symington, Lorraine S.
    [J]. NATURE, 2008, 455 (7214) : 770 - U3
  • [57] An RPA-Related Sequence-Specific DNA-Binding Subunit of Telomerase Holoenzyme Is Required for Elongation Processivity and Telomere Maintenance
    Min, Bosun
    Collins, Kathleen
    [J]. MOLECULAR CELL, 2009, 36 (04) : 609 - 619
  • [58] Structural basis for telomeric single-stranded DNA recognition by yeast Cdc13
    Mitton-Fry, RM
    Anderson, EM
    Theobald, DL
    Glustrom, LW
    Wuttke, DS
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2004, 338 (02) : 241 - 255
  • [59] Conserved structure for single-stranded telomeric DNA recognition
    Mitton-Fry, RM
    Anderson, EM
    Hughes, TR
    Lundblad, V
    Wuttke, DS
    [J]. SCIENCE, 2002, 296 (5565) : 145 - 147
  • [60] RPA-like Mammalian Ctc1-Stn1-Ten1 Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Pot1 Pathway
    Miyake, Yasuyuki
    Nakamura, Mirai
    Nabetani, Akira
    Shimamura, Shintaro
    Tamura, Miki
    Yonehara, Shin
    Saito, Motoki
    Ishikawa, Fuyuki
    [J]. MOLECULAR CELL, 2009, 36 (02) : 193 - 206
12345678910