CST Meets Shelterin to Keep Telomeres in Check

被引：115
作者：
Giraud-Panis, Marie-Josephe [1 ,2 ,3 ]
Teixeira, M. Teresa [3 ]
Geli, Vincent [4 ]
Gilson, Eric [1 ,2 ,3 ,5 ]
机构：
[1] Univ Nice, Lab Biol & Pathol Genomes, CNRS, INSERM,UMR 6267,U998,Fac Med, F-06107 Nice 2, France
[2] Univ Lyon, Lab Joliot Curie, Ecole Normale Super Lyon, F-69364 Lyon, France
[3] Univ Lyon, Lab Biol Mol Cellule, Ecole Normale Super Lyon, CNRS,UMR 5239, F-69364 Lyon, France
[4] CNRS, Instabilite Genome & Cancerogenese, CNRS, F-13402 Marseille 20, France
[5] Ctr Hosp Univ Nice, Dept Med Genet, Archet Hosp 2, F-06202 Nice, France
来源：
MOLECULAR CELL | 2010年 / 39卷 / 05期
关键词：
SINGLE-STRANDED-DNA; CHROMOSOME END-PROTECTION; POLYMERASE-ALPHA-PRIMASE; SACCHAROMYCES-CEREVISIAE; BINDING-PROTEIN; YEAST TELOMERASE; OB-FOLD; LENGTH REGULATION; MAMMALIAN TELOMERES; ACCESSORY PROTEIN;
D O I：
10.1016/j.molcel.2010.08.024
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Telomere protection in budding yeast requires the heterotrimer named CST (for Cdc13-Stn1-Ten1). Recent data show that CST components are conserved and required for telomere stability in a wide range of eukaryotes, even those utilizing the shelterin complex to protect their telomeres. A common function of these proteins might be to stimulate priming at the C-strand gap that remains after telomerase elongation, replication termination, and terminal processing. In light of the budding yeast situation, another conserved function of CST might well be the regulation of telomerase. The cohabitation at telomeres of CST and shelterin components highlights the complexity of telomere biology.
引用
收藏
页码：665 / 676
页数：12
相关论文
共 98 条
  • [1] A two-step model for senescence triggered by a single critically short telomere
    Abdallah, Pauline
    Luciano, Pierre
    Runge, Kurt W.
    Lisby, Michael
    Geli, Vincent
    Gilson, Eric
    Teixeira, M. Teresa
    [J]. NATURE CELL BIOLOGY, 2009, 11 (08) : 988 - U174
  • [2] TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo
    Abreu, Eladio
    Aritonovska, Elena
    Reichenbach, Patrick
    Cristofari, Gael
    Culp, Brad
    Terns, Rebecca M.
    Lingner, Joachim
    Terns, Michael P.
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2010, 30 (12) : 2971 - 2982
  • [3] Telomeric repeat-containing RNA and RNA surveillance factors at mammalian chromosome ends
    Azzalin, Claus M.
    Reichenbach, Patrick
    Khoriauli, Lela
    Giulotto, Elena
    Lingner, Joachim
    [J]. SCIENCE, 2007, 318 (5851) : 798 - 801
  • [4] Pot1, the putative telomere end-binding protein in fission yeast and humans
    Baumann, P
    Cech, TR
    [J]. SCIENCE, 2001, 292 (5519) : 1171 - 1175
  • [5] Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1
    Bianchi, A
    Negrini, S
    Shore, D
    [J]. MOLECULAR CELL, 2004, 16 (01) : 139 - 146
  • [6] Telomere states and cell fates
    Blackburn, EH
    [J]. NATURE, 2000, 408 (6808) : 53 - 56
  • [7] From RPA to BRCA2: lessons from single-stranded DNA binding by the OB-fold
    Bochkarev, A
    Bochkareva, E
    [J]. CURRENT OPINION IN STRUCTURAL BIOLOGY, 2004, 14 (01) : 36 - 42
  • [8] The crystal structure of the complex of replication protein A subunits RPA32 and RPA14 reveals a mechanism for single-stranded DNA binding
    Bochkarev, A
    Bochkareva, E
    Frappier, L
    Edwards, AM
    [J]. EMBO JOURNAL, 1999, 18 (16) : 4498 - 4504
  • [9] Structure of the major single-stranded DNA-binding domain of replication protein A suggests a dynamic mechanism for DNA binding
    Bochkareva, E
    Belegu, V
    Korolev, S
    Bochkarev, A
    [J]. EMBO JOURNAL, 2001, 20 (03) : 612 - 618
  • [10] Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA
    Bochkareva, E
    Korolev, S
    Lees-Miller, SP
    Bochkarev, A
    [J]. EMBO JOURNAL, 2002, 21 (07) : 1855 - 1863
12345678910