Short Alkylated Peptoid Mimics of Antimicrobial Lipopeptides

被引：112

作者：

Chongsiriwatana, Nathaniel P. ^{[1
]}

Miller, Tyler M. ^{[2
,3
]}

Wetzler, Modi ^{[3
]}

Vakulenko, Sergei ^{[4
]}

Karlsson, Amy J. ^{[4
]}

Palecek, Sean P. ^{[4
]}

Mobashery, Shahriar ^{[5
]}

Barron, Annelise E. ^{[1
,2
,3
,6
]}

机构：

[1] Northwestern Univ, Dept Chem & Biol Engn, Evanston, IL 60208 USA

[2] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[3] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[4] Univ Wisconsin, Dept Chem & Biol Engn, Madison, WI 53706 USA

[5] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

[6] Stanford Univ, Dept Chem Engn, Stanford, CA 94305 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 01期

关键词：

HOST-DEFENSE PEPTIDES; BETA-PEPTIDES; SIDE-CHAINS; IN-VITRO; SECONDARY STRUCTURE; PLAUSIBLE MODE; AMINO-ACID; OLIGOMERS; ANTIBACTERIAL; ANTIFUNGAL;

D O I：

10.1128/AAC.01080-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report the creation of alkylated poly-N-substituted glycine (peptoid) mimics of antimicrobial lipopeptides with alkyl tails ranging from 5 to 13 carbons. In several cases, alkylation significantly improved the selectivity of the peptoids with no loss in antimicrobial potency. Using this technique, we synthesized an antimicrobial peptoid only 5 monomers in length with selective, broad-spectrum antimicrobial activity as potent as previously reported dodecameric peptoids and the antimicrobial peptide pexiganan.

引用

页码：417 / 420

页数：4

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