Short Alkylated Peptoid Mimics of Antimicrobial Lipopeptides

被引：111
作者：
Chongsiriwatana, Nathaniel P. [1 ]
Miller, Tyler M. [2 ,3 ]
Wetzler, Modi [3 ]
Vakulenko, Sergei [4 ]
Karlsson, Amy J. [4 ]
Palecek, Sean P. [4 ]
Mobashery, Shahriar [5 ]
Barron, Annelise E. [1 ,2 ,3 ,6 ]
机构：
[1] Northwestern Univ, Dept Chem & Biol Engn, Evanston, IL 60208 USA
[2] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA
[3] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
[4] Univ Wisconsin, Dept Chem & Biol Engn, Madison, WI 53706 USA
[5] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA
[6] Stanford Univ, Dept Chem Engn, Stanford, CA 94305 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 01期
关键词：
HOST-DEFENSE PEPTIDES; BETA-PEPTIDES; SIDE-CHAINS; IN-VITRO; SECONDARY STRUCTURE; PLAUSIBLE MODE; AMINO-ACID; OLIGOMERS; ANTIBACTERIAL; ANTIFUNGAL;
D O I：
10.1128/AAC.01080-10
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We report the creation of alkylated poly-N-substituted glycine (peptoid) mimics of antimicrobial lipopeptides with alkyl tails ranging from 5 to 13 carbons. In several cases, alkylation significantly improved the selectivity of the peptoids with no loss in antimicrobial potency. Using this technique, we synthesized an antimicrobial peptoid only 5 monomers in length with selective, broad-spectrum antimicrobial activity as potent as previously reported dodecameric peptoids and the antimicrobial peptide pexiganan.
引用
收藏
页码：417 / 420
页数：4
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