Three dimensional volume measurement of mouse abdominal fat in magnetic resonance images

被引:0
作者
Chae, Yongsu [1 ]
Jeong, Myeong Gi [1 ]
Kim, Desok [1 ]
机构
[1] Informat & Commun Univ, Sch Engn, Taejon, South Korea
来源
HEALTHCOM 2007: UBIQUITOUS HEALTHCARE IN AGING SOCIETIES | 2007年
关键词
magnetic resonance imaging; three dimensional segmentation; thresholding; volume measurement; morphology;
D O I
暂无
中图分类号
TP [自动化技术、计算机技术];
学科分类号
0812 ;
摘要
Obesity adversely affects the health of people. Therapeutics against obesity could be validated by measuring the change of body fat tissues repeatedly in magnetic resonance (MR) images. In this study, an accurate method for three dimensional (3D) volume measurement of abdominal fat tissue has been developed for mouse MR images. The MR image was acquired by gradient echo technique and preprocessed by low pass filtering. 3D images were segmented by three-level adaptive thresholding based on the intensity histogram. Small objects were removed by erosion followed by binary reconstruction. Fat tissues were separated by ultimate erosion and individual labeling in 3D, followed by conditional dilation. Abdominal subcutaneous and visceral fat tissues were interactively classified and compared to manually obtained ground truth images. Measurement accuracy was greater than 83.4% for total body fat and 81.9% for abdominal visceral fat, showing the feasibility of routinely measuring the specific component of body fats in mice.
引用
收藏
页码:252 / +
页数:2
相关论文
共 20 条
[1]  
ABATE N, 1994, J LIPID RES, V35, P1490
[2]   Accurate quantification of visceral adipose tissue (VAT) using water-saturation MRI and computer segmentation: Preliminary results [J].
Armao, D ;
Guyon, JP ;
Firat, Z ;
Brown, MA ;
Sernelka, RC .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2006, 23 (05) :736-741
[3]  
BANDEKAR AN, 2005, IEEE EMBS, P3280
[4]   In vivo phenotyping of the ob/ob mouse by magnetic resonance imaging and 1H-Magnetic resonance spectroscopy [J].
Calderan, Laura ;
Marzola, Pasquina ;
Nicolato, Elena ;
Fabene, Paolo F. ;
Milanese, Chiara ;
Bernardi, Paolo ;
Giordano, Antonio ;
Cinti, Saverio ;
Sbarbati, Andrea .
OBESITY, 2006, 14 (03) :405-414
[5]  
CHAE Y, 2006, IN PRESS LECT NOTES
[6]   MRI of fat distribution in a mouse model of lysosomal acid lipase deficiency [J].
Du, H ;
Dardzinski, BJ ;
O'Brien, KJ ;
Donnelly, LF .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2005, 184 (02) :658-662
[7]  
ILEA D, 2004, OPTIMIZATION ELECT E, P227
[8]  
JORGENSEN PS, 2006, THESIS
[9]   A novel method of measuring intra-abdominal fat volume using helical computed tomography [J].
Kobayashi, J ;
Tadokoro, N ;
Watanbe, M ;
Shinomiya, M .
INTERNATIONAL JOURNAL OF OBESITY, 2002, 26 (03) :398-402
[10]   ABDOMINAL ADIPOSE-TISSUE DISTRIBUTION, OBESITY, AND RISK OF CARDIOVASCULAR-DISEASE AND DEATH - 13 YEAR FOLLOW UP OF PARTICIPANTS IN THE STUDY OF MEN BORN IN 1913 [J].
LARSSON, B ;
SVARDSUDD, K ;
WELIN, L ;
WILHELMSEN, L ;
BJORNTORP, P ;
TIBBLIN, G .
BRITISH MEDICAL JOURNAL, 1984, 288 (6428) :1401-1404