Expression of CD22 on peripheral B cells in patients with rheumatoid arthritis: relation to CD5-positive B cells

被引：9

作者：

Nakiri, Yutaka ^{[1
]}

Minowa, Kentarou ^{[1
]}

Suzuki, Jun ^{[1
]}

Mitsuo, Akiko ^{[1
]}

Amano, Hirofumi ^{[1
]}

Morimoto, Shinji ^{[1
]}

Tokano, Yoshiaki ^{[1
]}

Takasaki, Yoshinari ^{[1
]}

机构：

[1] Juntendo Univ, Sch Med, Dept Rheumatol & Internal Med, Bunkyo Ku, Tokyo 113, Japan

来源：

CLINICAL RHEUMATOLOGY | 2007年 / 26卷 / 10期

关键词：

B cells; CD5; CD22; rheumatoid arthritis (RA); rheumatoid factor (RF);

D O I：

10.1007/s10067-007-0665-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

B cells in patients with rheumatoid arthritis (RA) are hyperactivated. Although B cell receptor signal transduction may be affected by various response regulators, CD22 plays an important role as a response regulator of B cells. Therefore, we investigated and examined CD22 expression on peripheral blood B cells of patients with RA. Thirty-two RA patients and 16 controls were enrolled in this study, and CD22 expressions on B cells were analyzed by flow cytometry. In patients with RA, CD22(+) B cells significantly decreased in comparison to the controls (ratio: P<0.05). However, there was no correlation between this decrease and the clinical data. Interestingly, CD5(+) CD22(-) B cells significantly increased in RA patients. The decrease in CD22(+) B cells and increased in CD5(+)CD22(-) B cells play critical roles in the pathogenesis of RA mediated by the activation of B cells.

引用

页码：1721 / 1723

页数：3

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