Study on the Interaction Between Cholesterol and Amphotericin B in Mixed Monolayers

被引：0
|
作者：
Chang Yiguang [1 ]
Sun Runguang [1 ]
Hao Changchun [1 ]
Xue Huijun [1 ]
Han Tao [1 ]
Wang Xiaomei [1 ]
机构：
[1] Shaanxi Normal Univ, Lab Biophys & Biomed Engn, Coll Phys & Informat Technol, Xian 710062, Peoples R China
来源：
ACTA CHIMICA SINICA | 2010年 / 68卷 / 21期
关键词：
amphotericin B; monolayer; elastic modulus; excess Gibbs energy; interaction parameter; CELLULAR MEMBRANE-COMPONENTS; THERMODYNAMIC CHARACTERISTICS; BEHAVIOR; FILMS; INFECTIONS; STEROLS; SYSTEMS; FUNGAL;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Amphotericin B (AmB) is a widely used polyene antibiotic to treat systemic fungal infections, and the absorption process of AmB is related with biomembrane closely In this work, the interaction between AmB and cholesterol (an important biomembrane in cell membrane) was investigated in terms of the mean surface area per molecule (A), elastic modulus (C-s(-1)), surface excess Gibbs energy (Delta G(ex)) and interaction parameter (alpha) on the basis of surface pressure-area (pi-A) isotherms The results indicate that the compressibility, stability and thermodynamic characteristics of binary mixtures of cholesterol/AmB show a marked dependence on the mole faction of AmB and the surface pressure, which has been further proved by the interaction parameter alpha
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页码：2181 / 2185
页数：5
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