Solubility of L-Dopa in supercritical carbon dioxide: prediction using a cubic equation of state

被引：6
作者：
de Melo, SABV
de Melo, RLFV
Costa, GMN
Alves, TLM
机构：
[1] Univ Tiradentes, Inst Sci & Technol, ITP, UNIT, BR-49032490 Aracaju, SE, Brazil
[2] Univ Salvador, UNIFACS, BR-40220141 Salvador, BA, Brazil
[3] Univ Fed Rio de Janeiro, COPPE, PEQ, BR-21945 Rio De Janeiro, Brazil
来源：
JOURNAL OF SUPERCRITICAL FLUIDS | 2005年 / 34卷 / 02期
关键词：
L-Dopa; caffeic acid; solubility; supercritical carbon dioxide; cubic equation of state;
D O I：
10.1016/j.supflu.2004.11.019
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
An alternative way is presented to evaluate the possibility of supercritical fluid extraction of a solute when no experimental data on solubility is available. To predict the solubility Of L-Dopa (a drug commonly used for the treatment of Parkinson's disease) in supercritical CO2, the Peng-Robinson equation of state is applied in a fully predictive way with UNIFAC group contribution activity coefficient model incorporated in its mixing rules using the linear combination of Vidal and Michelsen (LCVM) procedure. Experimental solubility data of caffeic acid in SC-CO2 is used as the reference basis for this methodology and the results for L-Dopa solubility suggest further experimental studies. (c) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：231 / 236
页数：6
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